1s64 B 2.55 BS01 ZN B 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 B 2.55 BS02 778 B 1 R173 Q212 H219 G221 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 -logKd/Ki=8.40, Ki=4nM P53610 15248757 380 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 D 2.55 BS01 ZN D 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 D 2.55 BS02 778 D 1 R173 Q212 H219 G221 C225 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 C208 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 381 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 F 2.55 BS01 ZN F 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 F 2.55 BS02 778 F 1 R173 Q212 H219 G221 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 381 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 H 2.55 BS01 ZN H 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 H 2.55 BS02 778 H 1 R173 Q212 H219 G221 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 381 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 J 2.55 BS01 ZN J 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 J 2.55 BS02 778 J 1 R173 Q212 H219 G221 C225 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 C208 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 381 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 L 2.55 BS01 ZN L 1 D269 C271 H321 D252 C254 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 378 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT 1s64 L 2.55 BS02 778 L 1 R173 Q212 H219 G221 C225 D269 C271 Y272 W275 H321 R156 Q195 H202 G204 C208 D252 C254 Y255 W258 H304 H219 R263 K266 D269 C271 Y272 K311 D318 H321 H202 R246 K249 D252 C254 Y255 K294 D301 H304 2.5.1.59 0003824,0004659,0004661,0004662,0005515,0005953,0008270,0008284,0008318,0018344,0034097,0036094,0042277,0045787,0046872,0051771,1901363 P53610 15248757 381 LDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKT