1s63 A 1.9 BS01 GLC C 1 Y241 D286 Y187 D232 K164 K110 2.5.1.58,2.5.1.59 0004659,0004660,0004661,0004662,0004663,0005515,0005737,0005829,0005875,0005886,0005953,0005965,0007167,0007179,0007528,0008017,0008318,0018342,0018343,0018344,0030971,0035022,0043014,0060090,0071340,0090044,0090045,1904395 P49354 15248757 1 FVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHST 1s63 A 1.9 BS02 FPP B 1 K164 Y166 K110 Y112 K164 K110 2.5.1.58,2.5.1.59 0004659,0004660,0004661,0004662,0004663,0005515,0005737,0005829,0005875,0005886,0005953,0005965,0007167,0007179,0007528,0008017,0008318,0018342,0018343,0018344,0030971,0035022,0043014,0060090,0071340,0090044,0090045,1904395 Kd=2.0nM P49354 15248757 3011 FVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHST 1s63 B 1.9 BS01 GLC C 1 Q233 N234 W235 Q219 N220 W221 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 15248757 1 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 1s63 B 1.9 BS02 FRU C 1 Q233 N234 G237 N269 S272 Q219 N220 G223 N255 S258 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 15248757 2 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 1s63 B 1.9 BS03 ZN B 1 D297 C299 H362 D283 C285 H348 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 15248757 1001 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 1s63 B 1.9 BS04 FPP B 1 R202 H248 G250 Y251 C254 R291 K294 Y300 W303 R188 H234 G236 Y237 C240 R277 K280 Y286 W289 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 P49356 15248757 3011 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE 1s63 B 1.9 BS05 778 B 1 W102 W106 R202 D297 C299 Y361 H362 W88 W92 R188 D283 C285 Y347 H348 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H234 R277 K280 D283 C285 Y286 D338 D345 H348 2.5.1.58 0003824,0004659,0004660,0005515,0005829,0005875,0005965,0006629,0008270,0008318,0018343,0046872 Ki=0.9nM -logKd/Ki=9.05, Ki=0.9nM IC50=2nM P49356 15248757 3012 SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFE