1s2c A 1.8 BS01 NAP A 1 G22 T23 Y24 D50 Y55 H117 N167 Q190 Y216 S217 L219 S221 Q222 L236 A253 L268 K270 S271 R276 Q279 N280 G17 T18 Y19 D45 Y50 H112 N162 Q185 Y211 S212 L214 S216 Q217 L231 A248 L263 K265 S266 R271 Q274 N275 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 P42330 14996743 1001 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 1s2c A 1.8 BS02 FLF A 1 Y55 W86 H117 M120 N167 W227 F306 F311 Y50 W81 H112 M115 N162 W222 F301 F306 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 Ki~0.14uM IC50=51nM, Ki=140nM P42330 14996743 2001 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 1s2c A 1.8 BS03 FLF A 2 Q6 C7 V8 V18 L261 G264 V265 Q1 C2 V3 V13 L256 G259 V260 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 Ki~0.14uM IC50=51nM, Ki=140nM P42330 14996743 2002 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS