1ru1 A 1.4 BS01 MG A 1 D95 D97 D80 D82 R92 D95 D97 R77 D80 D82 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 P26281 14769023 161 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPPDYLNAAVALETSLAPEELLNHTQRIELQQGRRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 A 1.4 BS02 MG A 2 D95 D97 D80 D82 R92 D95 D97 R77 D80 D82 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 P26281 14769023 162 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPPDYLNAAVALETSLAPEELLNHTQRIELQQGRRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 A 1.4 BS03 APC A 1 Q74 D95 D97 I98 R110 L111 T112 H115 Y116 R121 Q68 D80 D82 I83 R95 L96 T97 H100 Y101 R106 R92 D95 D97 R77 D80 D82 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 -logKd/Ki=4.74, Kd=18uM P26281 14769023 171 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPPDYLNAAVALETSLAPEELLNHTQRIELQQGRRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 A 1.4 BS04 PH2 A 1 T42 P43 Y53 N55 D95 F123 T42 P43 Y47 N49 D80 F108 R92 D95 D97 R77 D80 D82 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 Kd=18uM P26281 14769023 181 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPPDYLNAAVALETSLAPEELLNHTQRIELQQGRRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 B 1.4 BS01 MG B 1 D295 D297 D89 D91 R292 D295 D297 R86 D89 D91 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 P26281 14769023 361 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRGGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 B 1.4 BS02 MG B 2 D295 D297 D89 D91 R292 D295 D297 R86 D89 D91 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 P26281 14769023 362 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRGGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 B 1.4 BS03 APC B 1 L270 D295 D297 I298 R310 L311 T312 H315 Y316 R321 L70 D89 D91 I92 R104 L105 T106 H109 Y110 R115 R292 D295 D297 R86 D89 D91 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 P26281 14769023 371 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRGGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW 1ru1 B 1.4 BS04 PH2 B 1 T242 P243 L245 Y253 N255 D295 F323 T42 P43 L45 Y53 N55 D89 F117 R292 D295 D297 R86 D89 D91 2.7.6.3 0000287,0003848,0005524,0009396,0016301,0016310,0046654,0046656 Kd=18uM P26281 14769023 381 TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRGGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW