1rtl A 2.75 BS01 peptide C 0 T4 A5 Y6 A7 Q8 Q9 T10 R11 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 W85 R109 T4 A5 Y6 A7 Q8 Q9 T10 R11 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 W85 R109 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26664 14627400 20 ~ 40 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR 1rtl A 2.75 BS02 peptide D 0 T4 A5 Y6 T4 A5 Y6 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26664 14627400 21 ~ 36 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR 1rtl A 2.75 BS03 ZN A 1 C97 C99 C145 C97 C99 C145 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26664 14627400 301 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR 1rtl A 2.75 BS04 CPX A 1 Q41 H57 I132 S139 F154 A156 A157 Q41 H57 I132 S139 F154 A156 A157 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 -logKd/Ki=5.59, IC50=2.6uM P26664 14627400 201 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR 1rtl B 2.75 BS01 peptide D 0 V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 P88 G90 V2 G4 E5 V6 I8 V9 S10 R35 T36 I37 P61 G63 H57 D81 G137 S139 H30 D54 G110 S112 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26664 14627400 21 ~ 36 QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR 1rtl B 2.75 BS02 ZN B 1 C97 C99 C145 C70 C72 C118 H57 D81 G137 S139 H30 D54 G110 S112 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P26664 14627400 301 QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLETTMR