1r37 A 2.3 BS01 ZN A 1 C38 H68 C154 C38 H68 C154 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 500 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 A 2.3 BS02 ZN A 2 E98 C101 C104 C112 E98 C101 C104 C112 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 400 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 A 2.3 BS03 NAD A 1 C38 H39 S40 H43 C154 T158 G181 G182 L183 D203 V204 R205 L247 N248 V270 G271 L272 F273 L295 V296 L334 F337 R342 C38 H39 S40 H43 C154 T158 G181 G182 L183 D203 V204 R205 L247 N248 V270 G271 L272 F273 L295 V296 L334 F337 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 Kd=0.66uM P39462 14661950 403 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 A 2.3 BS04 ETX A 1 S40 F49 S40 F49 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 600 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 B 2.3 BS01 ZN B 1 C38 H68 C154 C38 H68 C154 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 500 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 B 2.3 BS02 ZN B 2 E98 C101 C104 C112 E98 C101 C104 C112 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 400 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 B 2.3 BS03 NAD B 1 C38 H39 S40 H43 C154 T158 G178 G181 G182 L183 D203 V204 R205 L247 N248 V270 G271 L272 F273 L295 V296 L334 F337 C38 H39 S40 H43 C154 T158 G178 G181 G182 L183 D203 V204 R205 L247 N248 V270 G271 L272 F273 L295 V296 L334 F337 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 Kd=0.66uM P39462 14661950 403 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP 1r37 B 2.3 BS04 ETX B 1 S40 F49 H68 S40 F49 H68 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 C38 H39 S40 H43 H68 E69 E98 C101 C104 C112 R116 C154 T158 R342 1.1.1.1 0004022,0008270,0016491,0046872 P39462 14661950 600 MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP