1q6s A 2.2 BS01 214 A 1 R524 D529 Y546 R547 D548 F682 C715 S716 A717 I719 G720 R721 R754 M758 Q762 R28 D33 Y50 R51 D52 F186 C219 S220 A221 I223 G224 R225 R258 M262 Q266 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=12nM -logKd/Ki=7.92, IC50=12nM IC50=220nM P18031 14516196 801 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 1q6s A 2.2 BS02 214 B 1 A518 D522 H525 E526 A22 D26 H29 E30 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=12nM -logKd/Ki=7.92, IC50=12nM IC50=220nM P18031 14516196 1301 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 1q6s B 2.2 BS01 214 A 1 A1018 Q1021 D1022 A22 Q25 D26 D1181 C1215 R1221 S1222 Q1262 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=12nM IC50=220nM P18031 14516196 801 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 1q6s B 2.2 BS02 214 B 1 R1024 D1029 Y1046 R1047 D1048 L1119 F1182 C1215 S1216 A1217 I1219 G1220 R1221 R1254 M1258 Q1262 R28 D33 Y50 R51 D52 L123 F186 C219 S220 A221 I223 G224 R225 R258 M262 Q266 D1181 C1215 R1221 S1222 Q1262 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=12nM IC50=220nM P18031 14516196 1301 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS