1pl6 A 2.0 BS01 ZN A 1 C44 H69 C44 H69 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 402 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 A 2.0 BS02 NAD A 1 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 F297 R298 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 F297 R298 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 404 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 A 2.0 BS03 572 A 1 C44 S46 I56 F59 H69 E155 L274 F297 C44 S46 I56 F59 H69 E155 L274 F297 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Ki=154nM IC50=246nM Q00796 12962626 405 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 B 2.0 BS01 ZN B 1 C44 H69 C44 H69 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 402 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 B 2.0 BS02 NAD B 1 V159 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 R298 V159 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 R298 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 406 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 B 2.0 BS03 572 B 1 C44 S46 I56 F59 H69 E155 L274 F297 C44 S46 I56 F59 H69 E155 L274 F297 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Ki=154nM IC50=246nM Q00796 12962626 407 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 C 2.0 BS01 ZN C 1 C44 H69 C44 H69 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 402 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 C 2.0 BS02 NAD C 1 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 V296 R298 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 V296 R298 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 408 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 C 2.0 BS03 572 C 1 C44 S46 I56 F59 H69 E155 L274 F297 C44 S46 I56 F59 H69 E155 L274 F297 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Ki=154nM IC50=246nM Q00796 12962626 409 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 D 2.0 BS01 ZN D 1 C44 H69 C44 H69 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 402 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 D 2.0 BS02 NAD D 1 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 V296 F297 R298 G181 P182 I183 D203 L204 R208 C249 T250 V272 G273 L274 V296 F297 R298 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Q00796 12962626 410 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP 1pl6 D 2.0 BS03 572 D 1 C44 S46 I56 F59 H69 E155 L274 F297 C44 S46 I56 F59 H69 E155 L274 F297 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 C44 G45 S46 H49 H69 E70 R99 D102 C105 S113 F117 P156 G160 K344 1.1.1.-,1.1.1.14,1.1.1.4,1.1.1.56,1.1.1.9 0000721,0003824,0003939,0005615,0005739,0005829,0006006,0006060,0006062,0008270,0016020,0016491,0016616,0019640,0030246,0030317,0031514,0031966,0042802,0046370,0046526,0046872,0047833,0050255,0051160,0051164,0051287,0070062 Ki=154nM IC50=246nM Q00796 12962626 411 AAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP