1o5w A 3.2 BS01 FAD A 1 I19 G22 S24 E43 A44 R45 G50 R51 G66 G67 A68 Y69 P243 V244 I273 K305 W397 Y402 C406 Y407 G434 T435 G443 Y444 M445 I10 G13 S15 E34 A35 R36 G41 R42 G57 G58 A59 Y60 P234 V235 I264 K296 W388 Y393 C397 Y398 G425 T426 G434 Y435 M436 G71 R206 K305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 P21396 15050826 652 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYK 1o5w A 3.2 BS02 MLG A 1 I180 F208 Q215 C323 I335 T336 L337 Y407 Y444 I171 F199 Q206 C314 I326 T327 L328 Y398 Y435 G71 R206 K305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 IC50=2050nM, Ki=1200nM P21396 15050826 709 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYK 1o5w B 3.2 BS01 FAD B 1 I1019 G1022 I1023 S1024 E1043 A1044 R1045 G1050 R1051 G1066 G1067 A1068 Y1069 P1243 V1244 I1273 W1397 Y1402 C1406 Y1407 G1434 T1435 G1443 Y1444 M1445 A1448 I10 G13 I14 S15 E34 A35 R36 G41 R42 G57 G58 A59 Y60 P234 V235 I264 W388 Y393 C397 Y398 G425 T426 G434 Y435 M436 A439 G1071 R1206 K1305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 P21396 15050826 1652 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVA 1o5w B 3.2 BS02 MLG B 1 I1180 F1208 Q1215 C1323 I1335 T1336 Y1407 Y1444 I171 F199 Q206 C314 I326 T327 Y398 Y435 G1071 R1206 K1305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 IC50=2050nM, Ki=1200nM P21396 15050826 1709 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVA 1o5w C 3.2 BS01 FAD C 1 I2019 G2022 S2024 E2043 A2044 R2045 G2050 R2051 G2066 G2067 A2068 Y2069 P2243 V2244 I2273 W2397 Y2402 C2406 Y2407 G2434 T2435 G2443 Y2444 M2445 I10 G13 S15 E34 A35 R36 G41 R42 G57 G58 A59 Y60 P234 V235 I264 W388 Y393 C397 Y398 G425 T426 G434 Y435 M436 G2071 R2206 K2305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 P21396 15050826 2652 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKI 1o5w C 3.2 BS02 MLG C 1 I2180 F2208 Q2215 C2323 I2325 I2335 T2336 Y2407 Y2444 I171 F199 Q206 C314 I316 I326 T327 Y398 Y435 G2071 R2206 K2305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 IC50=2050nM, Ki=1200nM P21396 15050826 2709 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKI 1o5w D 3.2 BS01 FAD D 1 I3019 G3022 S3024 E3043 A3044 R3045 G3050 R3051 G3066 G3067 A3068 Y3069 P3243 V3244 I3273 K3305 W3397 Y3402 C3406 Y3407 G3434 T3435 G3443 Y3444 M3445 A3448 I10 G13 S15 E34 A35 R36 G41 R42 G57 G58 A59 Y60 P234 V235 I264 K296 W388 Y393 C397 Y398 G425 T426 G434 Y435 M436 A439 G3071 R3206 K3305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 P21396 15050826 3652 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLC 1o5w D 3.2 BS02 MLG D 1 I3180 F3208 Q3215 C3323 I3335 T3336 Y3407 Y3444 I171 F199 Q206 C314 I326 T327 Y398 Y435 G3071 R3206 K3305 G62 R197 K296 1.4.3.21,1.4.3.4 0005739,0005741,0006584,0008131,0009967,0016491,0042420,0042424,0042428,0042443,0050660,0051378,0052595,0097621 IC50=2050nM, Ki=1200nM P21396 15050826 3709 AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLC