1nu1 C 3.2 BS01 HEM C 1 Q44 I45 G48 L49 L51 Y55 R80 H83 A87 T126 G130 Y131 L133 P134 H182 P186 Q43 I44 G47 L48 L50 Y54 R79 H82 A86 T125 G129 Y130 L132 P133 H181 P185 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 P00157 12885240 381 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1nu1 C 3.2 BS02 HEM C 2 W31 G34 L37 H97 R100 S106 T112 W113 G116 V117 L119 H196 L200 S205 W30 G33 L36 H96 R99 S105 T111 W112 G115 V116 L118 H195 L199 S204 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 P00157 12885240 382 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1nu1 C 3.2 BS03 QNO C 1 F18 I27 S35 F220 Y224 D228 F17 I26 S34 F219 Y223 D227 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 -logKd/Ki=7.19, Kd=64nM P00157 12885240 383 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1nu1 D 3.2 BS01 HEM D 1 C37 C40 H41 N105 P110 R120 Y126 L130 L131 F153 G159 M160 A161 P163 C37 C40 H41 N105 P110 R120 Y126 L130 L131 F153 G159 M160 A161 P163 7.1.1.8 0009055,0020037 P00125 12885240 242 SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDEAKALAEEVEVQDGPNEDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYNEVLEFDDGTPATMSQVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLLPLVYAMKRHKWSVLKSRKLAYRPPK 1nu1 E 3.2 BS01 FES E 1 C139 H141 L142 C144 C158 C160 H161 S163 C139 H141 L142 C144 C158 C160 H161 S163 H161 H161 7.1.1.8 0008121,0016020,0051537 P13272 12885240 200 SHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPSYEFTSDDMVIVG