1niu A 2.2 BS01 DCS A 1 K39 Y43 L85 R136 H166 S204 R219 G221 I222 Y354 K38 Y42 L84 R135 H165 S203 R218 G220 I221 Y353 K39 R136 H166 R219 Y265 C311 D313 K38 R135 H165 R218 Y264 C310 D312 5.1.1.1 0003824,0005829,0006522,0008784,0009252,0016853,0030170,0030632 Ki=0.08uM P10724 12741835 800 NDFHRDTWAEVDLDAIYDNVENLRRLLPDDTHIMAVVKANAYGHGDVQVARTALEAGASRLAVAFLDEALALREKGIEAPILVLGASRPADAALAAQQRIALTVFRSDWLEEASALYSGPFPIHFHLKMDTGMGRLGVKDEEETKRIVALIERHPHFVLEGLYTHFATADEVNTDYFSYQYTRFLHMLEWLPSRPPLVHCANSAASLRFPDRTFNMVRFGIAMYGLAPSPGIKPLLPYPLKEAFSLHSRLVHVKKLQPGEKVSYGATYTAQTEEWIGTIPIGYADGWLRRLQHFHVLVDGQKAPIVGRICMDQCMIRLPGPLPVGTKVTLIGRQGDEVISIDDVARHLETINYEVPCTISYRVPRIFFRHKRIMEVRNAIGR 1niu A 2.2 BS02 DCS B 1 Y265 C311 M312 Y264 C310 M311 K39 R136 H166 R219 Y265 C311 D313 K38 R135 H165 R218 Y264 C310 D312 5.1.1.1 0003824,0005829,0006522,0008784,0009252,0016853,0030170,0030632 Ki=0.08uM P10724 12741835 900 NDFHRDTWAEVDLDAIYDNVENLRRLLPDDTHIMAVVKANAYGHGDVQVARTALEAGASRLAVAFLDEALALREKGIEAPILVLGASRPADAALAAQQRIALTVFRSDWLEEASALYSGPFPIHFHLKMDTGMGRLGVKDEEETKRIVALIERHPHFVLEGLYTHFATADEVNTDYFSYQYTRFLHMLEWLPSRPPLVHCANSAASLRFPDRTFNMVRFGIAMYGLAPSPGIKPLLPYPLKEAFSLHSRLVHVKKLQPGEKVSYGATYTAQTEEWIGTIPIGYADGWLRRLQHFHVLVDGQKAPIVGRICMDQCMIRLPGPLPVGTKVTLIGRQGDEVISIDDVARHLETINYEVPCTISYRVPRIFFRHKRIMEVRNAIGR 1niu B 2.2 BS01 DCS A 1 Y265 C311 M312 Y264 C310 M311 K39 R136 H166 R219 Y265 C311 D313 K38 R135 H165 R218 Y264 C310 D312 5.1.1.1 0003824,0005829,0006522,0008784,0009252,0016853,0030170,0030632 Ki=0.08uM P10724 12741835 800 NDFHRDTWAEVDLDAIYDNVENLRRLLPDDTHIMAVVKANAYGHGDVQVARTALEAGASRLAVAFLDEALALREKGIEAPILVLGASRPADAALAAQQRIALTVFRSDWLEEASALYSGPFPIHFHLKMDTGMGRLGVKDEEETKRIVALIERHPHFVLEGLYTHFATADEVNTDYFSYQYTRFLHMLEWLPSRPPLVHCANSAASLRFPDRTFNMVRFGIAMYGLAPSPGIKPLLPYPLKEAFSLHSRLVHVKKLQPGEKVSYGATYTAQTEEWIGTIPIGYADGWLRRLQHFHVLVDGQKAPIVGRICMDQCMIRLPGPLPVGTKVTLIGRQGDEVISIDDVARHLETINYEVPCTISYRVPRIFFRHKRIMEVRNAI 1niu B 2.2 BS02 DCS B 1 K39 Y43 L85 R136 H166 N203 S204 R219 G221 I222 Y354 K38 Y42 L84 R135 H165 N202 S203 R218 G220 I221 Y353 K39 R136 H166 R219 Y265 C311 D313 K38 R135 H165 R218 Y264 C310 D312 5.1.1.1 0003824,0005829,0006522,0008784,0009252,0016853,0030170,0030632 Ki=0.08uM P10724 12741835 900 NDFHRDTWAEVDLDAIYDNVENLRRLLPDDTHIMAVVKANAYGHGDVQVARTALEAGASRLAVAFLDEALALREKGIEAPILVLGASRPADAALAAQQRIALTVFRSDWLEEASALYSGPFPIHFHLKMDTGMGRLGVKDEEETKRIVALIERHPHFVLEGLYTHFATADEVNTDYFSYQYTRFLHMLEWLPSRPPLVHCANSAASLRFPDRTFNMVRFGIAMYGLAPSPGIKPLLPYPLKEAFSLHSRLVHVKKLQPGEKVSYGATYTAQTEEWIGTIPIGYADGWLRRLQHFHVLVDGQKAPIVGRICMDQCMIRLPGPLPVGTKVTLIGRQGDEVISIDDVARHLETINYEVPCTISYRVPRIFFRHKRIMEVRNAI