1n78 A 2.1 BS01 rna C 0 S9 T43 D44 R47 V145 R163 V166 Y168 E172 V177 K180 S181 Y187 E207 E208 W209 L210 V211 R237 K241 M273 G274 E282 R297 P303 V304 K309 W312 R319 P357 R358 R417 L427 Q432 R435 L442 E443 T444 G446 L447 F448 S9 T43 D44 R47 V145 R163 V166 Y168 E172 V177 K180 S181 Y187 E207 E208 W209 L210 V211 R237 K241 M273 G274 E282 R297 P303 V304 K309 W312 R319 P357 R358 R417 L427 Q432 R435 L442 E443 T444 G446 L447 F448 K246 K246 6.1.1.17 0000049,0000166,0004812,0004818,0005524,0005737,0005829,0006412,0006418,0006424,0008270,0043039 Ki=3uM P27000 12554668 501 ~ 576 MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKVPRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSHTSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRRAVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA 1n78 A 2.1 BS02 GOM A 1 R5 A7 P8 S9 G17 T18 I21 E41 Y187 N191 R205 A206 E208 W209 L235 L236 R5 A7 P8 S9 G17 T18 I21 E41 Y187 N191 R205 A206 E208 W209 L235 L236 K246 K246 6.1.1.17 0000049,0000166,0004812,0004818,0005524,0005737,0005829,0006412,0006418,0006424,0008270,0043039 P27000 12554668 600 MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKVPRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSHTSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRRAVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA 1n78 B 2.1 BS01 rna D 0 S9 T43 R47 V145 R163 V166 Y168 E172 V177 K180 S181 Y187 E207 E208 W209 L210 R237 K241 T242 K243 G274 E282 L300 P303 V304 E308 K309 W312 R319 P357 R358 R417 L427 Q432 R435 L442 E443 T444 G446 L447 F448 S9 T43 R47 V145 R163 V166 Y168 E172 V177 K180 S181 Y187 E207 E208 W209 L210 R237 K241 T242 K243 G274 E282 L300 P303 V304 E308 K309 W312 R319 P357 R358 R417 L427 Q432 R435 L442 E443 T444 G446 L447 F448 K246 K246 6.1.1.17 0000049,0000166,0004812,0004818,0005524,0005737,0005829,0006412,0006418,0006424,0008270,0043039 Ki=3uM P27000 12554668 501 ~ 576 MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKVPRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSHTSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRRAVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA 1n78 B 2.1 BS02 GOM B 1 R5 A7 S9 G17 T18 I21 E41 Y187 N191 R205 A206 W209 L235 L236 R5 A7 S9 G17 T18 I21 E41 Y187 N191 R205 A206 W209 L235 L236 K246 K246 6.1.1.17 0000049,0000166,0004812,0004818,0005524,0005737,0005829,0006412,0006418,0006424,0008270,0043039 P27000 12554668 601 MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKVPRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSHTSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRRAVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA