1m51 A 2.25 BS01 MN A 1 K244 H264 D311 K233 H253 D300 R87 Y235 K244 H264 S286 C288 D311 R405 R78 Y224 K233 H253 S275 C277 D300 R394 2.7.11.-,4.1.1.32 0000287,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070062,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 P35558 14552798 701 NLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWDKEVEDIEKYLVDQVNADLPCEIEREILALKQRISQM 1m51 A 2.25 BS02 TSX A 1 N292 L293 W516 F517 F525 P528 F530 N533 N281 L282 W497 F498 F506 P509 F511 N514 R87 Y235 K244 H264 S286 C288 D311 R405 R78 Y224 K233 H253 S275 C277 D300 R394 2.7.11.-,4.1.1.32 0000287,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070062,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 ic50=18.8uM -logKd/Ki=4.73, IC50=18.8uM P35558 14552798 1001 NLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWDKEVEDIEKYLVDQVNADLPCEIEREILALKQRISQM