1lvc A 3.6 BS01 DOT A 1 K346 H351 K353 S354 K382 E386 D493 H577 G578 T579 N583 F586 K55 H60 K62 S63 K91 E95 D202 H286 G287 T288 N292 F295 4.6.1.1 0005576,0008294 -logKd/Ki=6.00, Kd=1uM P40136 12485993 999 RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID 1lvc C 3.6 BS01 DOT C 1 K346 H351 S354 K382 E386 D493 H577 N583 F586 K55 H60 S63 K91 E95 D202 H286 N292 F295 4.6.1.1 0005576,0008294 P40136 12485993 1999 RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID 1lvc D 3.6 BS01 CA D 1 D129 D131 D133 Q135 E140 D125 D127 D129 Q131 E136 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 800 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 1lvc D 3.6 BS02 CA D 2 D93 D95 N97 Y99 I100 E104 D89 D91 N93 Y95 I96 E100 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 801 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 1lvc E 3.6 BS01 CA E 1 D129 D131 D133 Q135 E140 D125 D127 D129 Q131 E136 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 802 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 1lvc E 3.6 BS02 CA E 2 D93 D95 N97 Y99 I100 E104 D89 D91 N93 Y95 I96 E100 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 803 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 1lvc F 3.6 BS01 CA F 1 D129 D131 D133 Q135 V136 E140 D125 D127 D129 Q131 V132 E136 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 804 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 1lvc F 3.6 BS02 CA F 2 D93 D95 N97 Y99 I100 E104 D89 D91 N93 Y95 I96 E100 V35 V31 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 12485993 805 TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA