1lox A 2.4 BS01 FE2 A 1 H361 H366 H541 H545 I663 H347 H352 H527 H531 I647 H361 H366 H541 H545 I663 H347 H352 H527 H531 I647 1.13.11.-,1.13.11.12,1.13.11.31,1.13.11.33 0001503,0002820,0004052,0005506,0005546,0005737,0005811,0005829,0005886,0006629,0006631,0006646,0008289,0009898,0010811,0016020,0016165,0016702,0019369,0019372,0019395,0030282,0030838,0034440,0034976,0035358,0035963,0042060,0043277,0043651,0046872,0050473,0050727,0051122,0051213,0070374,0071277,1901074,2001303 P12530 9406550 840 GVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFELKNSLNILAPWKTLDDFNRIFWRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLKQSSLQMSIVWQLGRDIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI 1lox A 2.4 BS02 RS7 A 1 E357 H361 L362 H366 L408 F415 H545 Q548 I593 L597 E343 H347 L348 H352 L394 F401 H531 Q534 I579 L583 H361 H366 H541 H545 I663 H347 H352 H527 H531 I647 1.13.11.-,1.13.11.12,1.13.11.31,1.13.11.33 0001503,0002820,0004052,0005506,0005546,0005737,0005811,0005829,0005886,0006629,0006631,0006646,0008289,0009898,0010811,0016020,0016165,0016702,0019369,0019372,0019395,0030282,0030838,0034440,0034976,0035358,0035963,0042060,0043277,0043651,0046872,0050473,0050727,0051122,0051213,0070374,0071277,1901074,2001303 Ki=3uM -logKd/Ki=5.52, Ki=3uM P12530 9406550 841 GVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFELKNSLNILAPWKTLDDFNRIFWRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLKQSSLQMSIVWQLGRDIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI