1kz8 A 2.0 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 E280 D105 N196 Y199 Y228 S231 M232 Y248 K258 E264 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 736 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 A 2.0 BS02 MN A 1 E97 D118 E81 D102 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 739 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 A 2.0 BS03 AMP A 1 Q20 G21 A24 G26 T27 G28 E29 M30 K112 Y113 R140 M177 Q12 G13 A16 G18 T19 G20 E21 M22 K96 Y97 R124 M161 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 IC50=1300nM P00636 12190310 737 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 A 2.0 BS04 PFE A 1 K50 I53 H55 L56 K71 L73 K42 I45 H47 L48 K55 L57 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 ic50=0.83uM -logKd/Ki=6.08, IC50=0.83uM P00636 12190310 738 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 F 2.0 BS01 F6P F 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 E280 D105 N196 Y199 Y228 S231 M232 Y248 K258 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 836 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 F 2.0 BS02 MN F 1 D118 D121 E280 D102 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 839 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 F 2.0 BS03 AMP F 1 G21 A24 G26 T27 E29 M30 K112 Y113 R140 M177 G13 A16 G18 T19 E21 M22 K96 Y97 R124 M161 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 IC50=1300nM P00636 12190310 837 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 F 2.0 BS04 PFE F 1 K50 I53 H55 L56 K71 L73 K42 I45 H47 L48 K55 L57 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 ic50=0.83uM -logKd/Ki=6.08, IC50=0.83uM P00636 12190310 838 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA