1k0u A 3.0 BS01 NAD A 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 T274 T275 I280 I298 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 T273 T274 I279 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 1432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u A 3.0 BS02 DEA A 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 1433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u A 3.0 BS03 NAD B 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 2432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u B 3.0 BS01 NAD A 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 1432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u B 3.0 BS02 NAD B 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 T275 I280 I298 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 T274 I279 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 2432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u B 3.0 BS03 DEA B 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 F361 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 2433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u C 3.0 BS01 NAD C 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 N247 T275 I280 I298 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 N246 T274 I279 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 3432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u C 3.0 BS02 DEA C 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 F361 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 3433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u C 3.0 BS03 NAD D 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 4432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u D 3.0 BS01 NAD C 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 3432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u D 3.0 BS02 NAD D 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 N247 T275 I280 I298 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 N246 T274 I279 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 4432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u D 3.0 BS03 DEA D 1 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 F361 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 4433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u E 3.0 BS01 NAD E 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 N247 T275 I280 I298 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 N246 T274 I279 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 5432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u E 3.0 BS02 DEA E 1 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 5433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u E 3.0 BS03 NAD F 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 6432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u F 3.0 BS01 NAD E 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 5432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u F 3.0 BS02 NAD F 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 N247 T274 T275 I280 I298 G299 H300 L343 N345 H352 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 N246 T273 T274 I279 I297 G298 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 6432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u F 3.0 BS03 DEA F 1 T56 E58 D130 E155 T156 K185 D189 L346 G351 H352 M357 T55 E57 D129 E154 T155 K184 D188 L345 G350 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 6433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u G 3.0 BS01 NAD G 1 T156 T157 T158 N190 C194 G219 G221 V223 T241 E242 I243 N247 T274 T275 I298 H300 L343 N345 H352 T155 T156 T157 N189 C193 G218 G220 V222 T240 E241 I242 N246 T273 T274 I297 H299 L342 N344 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 7432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u G 3.0 BS02 DEA G 1 T56 E58 D130 E155 T156 K185 D189 L346 G351 H352 T55 E57 D129 E154 T155 K184 D188 L345 G350 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 7433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u G 3.0 BS03 NAD H 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 8432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u H 3.0 BS01 NAD G 1 K425 Y429 K424 Y428 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 7432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u H 3.0 BS02 NAD H 1 T156 T157 T158 N190 G219 G221 V223 T241 E242 I243 N247 T274 T275 I298 G299 H300 L343 N345 T155 T156 T157 N189 G218 G220 V222 T240 E241 I242 N246 T273 T274 I297 G298 H299 L342 N344 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 P10760 11741948 8432 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u H 3.0 BS03 DEA H 1 T56 E58 E155 K185 D189 L346 H352 M357 T55 E57 E154 K184 D188 L345 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 8433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY