1jqd A 2.28 BS01 SAH A 1 G60 E89 P90 Q94 T119 S120 I142 Q143 M144 Y147 G54 E83 P84 Q88 T113 S114 I136 Q137 M138 Y141 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=6.9uM -logKd/Ki=5.16, Ki=6.9uM Ki=18100nM P50135 11566133 400 MRSLFHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 1jqd A 2.28 BS02 HSM A 1 F22 E28 Q143 N283 F16 E22 Q137 N277 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 P50135 11566133 600 MRSLFHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 1jqd B 2.28 BS01 SAH B 1 G60 G62 E89 P90 Q94 T119 S120 I142 Q143 M144 Y147 G56 G58 E85 P86 Q90 T115 S116 I138 Q139 M140 Y143 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=6.9uM Ki=18100nM P50135 11566133 401 MRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 1jqd B 2.28 BS02 HSM B 1 F22 E28 Q143 Y146 W179 N283 F18 E24 Q139 Y142 W175 N279 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 P50135 11566133 601 MRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA