1jjt A 1.8 BS01 ZN A 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 251 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jjt A 1.8 BS02 ZN A 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 252 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jjt A 1.8 BS03 ZN A 3 H34 E199 H32 E197 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 261 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jjt A 1.8 BS04 BDS A 1 V25 W28 F51 H79 S80 D81 H139 C158 K161 G166 N167 H197 V23 W26 F49 H77 S78 D79 H137 C156 K159 G164 N165 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 ic50=0.009uM -logKd/Ki=8.05, IC50=9nM Q79MP6 11390410 250 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jjt B 1.8 BS01 ZN B 1 H77 H79 H139 H76 H78 H138 H77 H79 D81 H139 C158 K161 N167 H197 H76 H78 D80 H138 C157 K160 N166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 251 ESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jjt B 1.8 BS02 ZN B 2 D81 C158 H197 D80 C157 H196 H77 H79 D81 H139 C158 K161 N167 H197 H76 H78 D80 H138 C157 K160 N166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 252 ESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jjt B 1.8 BS03 ZN B 3 H34 E199 H33 E198 H77 H79 D81 H139 C158 K161 N167 H197 H76 H78 D80 H138 C157 K160 N166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 261 ESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jjt B 1.8 BS04 BDS B 1 W28 H79 S80 D81 H139 C158 K161 G166 N167 H197 W27 H78 S79 D80 H138 C157 K160 G165 N166 H196 H77 H79 D81 H139 C158 K161 N167 H197 H76 H78 D80 H138 C157 K160 N166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 ic50=0.009uM Q79MP6 11390410 250 ESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK