1jje A 1.8 BS01 ZN A 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 251 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jje A 1.8 BS02 ZN A 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 252 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jje A 1.8 BS03 ZN A 3 H34 E199 H32 E197 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 261 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jje A 1.8 BS04 BYS A 1 V25 W28 H79 D81 H139 C158 K161 G166 N167 H197 V23 W26 H77 D79 H137 C156 K159 G164 N165 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 ic50=0.0037uM -logKd/Ki=8.43, IC50=3.7nM Q79MP6 11390410 250 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK 1jje B 1.8 BS01 ZN B 1 H77 H79 H139 H77 H79 H139 H77 H79 D81 H139 C158 K161 N167 H197 H77 H79 D81 H139 C158 K161 N167 H197 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 251 AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jje B 1.8 BS02 ZN B 2 D81 C158 H197 D81 C158 H197 H77 H79 D81 H139 C158 K161 N167 H197 H77 H79 D81 H139 C158 K161 N167 H197 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 252 AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jje B 1.8 BS03 ZN B 3 H34 E199 H34 E199 H77 H79 D81 H139 C158 K161 N167 H197 H77 H79 D81 H139 C158 K161 N167 H197 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Q79MP6 11390410 261 AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 1jje B 1.8 BS04 BYS B 1 W28 H79 D81 H139 C158 K161 G166 N167 H197 W28 H79 D81 H139 C158 K161 G166 N167 H197 H77 H79 D81 H139 C158 K161 N167 H197 H77 H79 D81 H139 C158 K161 N167 H197 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 ic50=0.0037uM Q79MP6 11390410 250 AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK