1j3i A 2.33 BS01 WRA A 1 I14 C15 D54 M55 F58 P113 F116 I164 I14 C15 D54 M55 F58 P103 F106 I154 L46 D54 L46 D54 1.5.1.3,2.1.1.45 0004146,0046654,0050661 Ki=0.011nM IC50=0.570000nM, Ki=0.5nM P13922 12704428 609 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKM 1j3i A 2.33 BS02 NDP A 1 C15 A16 L40 G44 V45 L46 G105 R106 T107 S108 L127 S128 R129 T130 N144 I164 G166 S167 V168 V169 E172 C15 A16 L40 G44 V45 L46 G95 R96 T97 S98 L117 S118 R119 T120 N134 I154 G156 S157 V158 V159 E162 L46 D54 L46 D54 1.5.1.3,2.1.1.45 0004146,0046654,0050661 P13922 12704428 610 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKM 1j3i B 2.33 BS01 WRA B 1 I14 C15 L46 D54 M55 F58 P113 I164 I13 C14 L45 D53 M54 F57 P108 I159 L46 D54 L45 D53 1.5.1.3,2.1.1.45 0004146,0046654,0050661 Ki=0.011nM IC50=0.570000nM, Ki=0.5nM P13922 12704428 709 MEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNN 1j3i B 2.33 BS02 NDP B 1 C15 A16 L40 G44 V45 G105 R106 S108 L127 S128 R129 T130 K145 V146 I164 G166 S167 V168 V169 Y170 E172 C14 A15 L39 G43 V44 G100 R101 S103 L122 S123 R124 T125 K140 V141 I159 G161 S162 V163 V164 Y165 E167 L46 D54 L45 D53 1.5.1.3,2.1.1.45 0004146,0046654,0050661 P13922 12704428 710 MEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNN 1j3i C 2.33 BS01 UMP C 1 R345 C490 H491 Q509 R510 S511 D513 N521 H551 Y553 R64 C209 H210 Q228 R229 S230 D232 N240 H270 Y272 E382 W404 Y430 C490 R510 D513 E101 W123 Y149 C209 R229 D232 1.5.1.3,2.1.1.45 0004799,0006231,0016741 P13922 12704428 611 DDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 1j3i C 2.33 BS02 UMP D 1 R470 R471 R189 R190 E382 W404 Y430 C490 R510 D513 E101 W123 Y149 C209 R229 D232 1.5.1.3,2.1.1.45 0004799,0006231,0016741 P13922 12704428 711 DDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 1j3i D 2.33 BS01 UMP C 1 R470 R471 R190 R191 E382 W404 Y430 C490 R510 D513 E102 W124 Y150 C210 R230 D233 1.5.1.3,2.1.1.45 0004799,0006231,0016741 P13922 12704428 611 DDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 1j3i D 2.33 BS02 UMP D 1 R345 C490 H491 Q509 R510 S511 D513 G517 N521 H551 Y553 R65 C210 H211 Q229 R230 S231 D233 G237 N241 H271 Y273 E382 W404 Y430 C490 R510 D513 E102 W124 Y150 C210 R230 D233 1.5.1.3,2.1.1.45 0004799,0006231,0016741 P13922 12704428 711 DDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA