1i32 A 2.6 BS01 NMD A 1 G9 D38 M39 S40 A90 Q91 R92 T111 G9 D38 M39 S40 A90 Q91 R92 T111 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 -logKd/Ki=5.70, IC50=2uM Q27890 11371162 361 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 B 2.6 BS01 NMD B 1 G9 G11 D38 M39 S40 A90 Q91 R92 T111 L113 G9 G11 D38 M39 S40 A90 Q91 R92 T111 L113 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 -logKd/Ki=5.70, IC50=2uM Q27890 11371162 362 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 C 2.6 BS01 NMD C 1 G9 G11 V37 D38 M39 S40 A90 Q91 R92 T111 G9 G11 V37 D38 M39 S40 A90 Q91 R92 T111 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 Q27890 11371162 363 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 D 2.6 BS01 NMD C 1 V206 L208 V206 L208 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 Q27890 11371162 363 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 D 2.6 BS02 NMD D 1 G9 G11 D38 M39 A90 Q91 R92 T111 L113 G9 G11 D38 M39 A90 Q91 R92 T111 L113 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 Q27890 11371162 364 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 E 2.6 BS01 NMD E 1 G9 G11 D38 M39 S40 A90 Q91 R92 T111 L113 G9 G11 D38 M39 S40 A90 Q91 R92 T111 L113 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 Q27890 11371162 365 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS 1i32 F 2.6 BS01 NMD F 1 G9 G11 D38 M39 S40 A90 R92 T111 L113 G9 G11 D38 M39 S40 A90 R92 T111 L113 C166 H194 C166 H194 1.2.1.12 0004365,0005829,0006006,0006096,0016491,0016620,0020015,0050661,0051287 Q27890 11371162 366 APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS