1hyo A 1.3 BS01 MG A 1 D233 W234 K253 G256 T257 D233 W234 K253 G256 T257 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1004 MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPAL 1hyo A 1.3 BS02 CA A 1 D126 E199 E201 D233 D126 E199 E201 D233 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1006 MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPAL 1hyo A 1.3 BS03 ACT A 1 Y128 R142 Y128 R142 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1009 MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPAL 1hyo A 1.3 BS04 HBU A 1 D126 F127 Y128 H133 Y159 K253 G349 T350 D126 F127 Y128 H133 Y159 K253 G349 T350 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 D126 H133 E199 E201 D233 R237 Q240 K253 T257 E364 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 Ki=84.8uM P35505 11154690 1012 MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPAL 1hyo B 1.3 BS01 MG B 1 D733 W734 K753 G756 T757 D235 W236 K255 G258 T259 D626 H633 E699 E701 D733 R737 Q740 K753 T757 E864 D128 H135 E201 E203 D235 R239 Q242 K255 T259 E366 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1005 GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALS 1hyo B 1.3 BS02 CA B 1 D626 E699 E701 D733 D128 E201 E203 D235 D626 H633 E699 E701 D733 R737 Q740 K753 T757 E864 D128 H135 E201 E203 D235 R239 Q242 K255 T259 E366 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1007 GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALS 1hyo B 1.3 BS03 ACT B 1 Y628 V637 R642 Y130 V139 R144 D626 H633 E699 E701 D733 R737 Q740 K753 T757 E864 D128 H135 E201 E203 D235 R239 Q242 K255 T259 E366 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 P35505 11154690 1010 GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALS 1hyo B 1.3 BS04 HBU B 1 D626 F627 Y628 H633 Y659 K753 G849 T850 D128 F129 Y130 H135 Y161 K255 G351 T352 D626 H633 E699 E701 D733 R737 Q740 K753 T757 E864 D128 H135 E201 E203 D235 R239 Q242 K255 T259 E366 3.7.1.2 0003824,0004334,0006527,0006559,0006572,0006629,0009072,0016787,0046872 Ki=84.8uM P35505 11154690 1011 GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALS