1hy7 A 1.5 BS01 ZN A 1 H201 H205 H211 H119 H123 H129 H201 H205 H211 H119 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 301 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDDINGIQSLYGPPP 1hy7 A 1.5 BS02 ZN A 2 H151 D153 H166 H179 H69 D71 H84 H97 H201 H205 H211 H119 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 302 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDDINGIQSLYGPPP 1hy7 A 1.5 BS03 CA A 1 D158 G159 G161 V163 D181 E184 D76 G77 G79 V81 D99 E102 H201 H205 H211 H119 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 303 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDDINGIQSLYGPPP 1hy7 A 1.5 BS04 CA A 2 D107 D182 E184 D25 D100 E102 H201 H205 H211 H119 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 304 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDDINGIQSLYGPPP 1hy7 A 1.5 BS05 CA A 3 D141 G173 N175 D177 D59 G91 N93 D95 H201 H205 H211 H119 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 305 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDDINGIQSLYGPPP 1hy7 B 1.5 BS01 ZN B 1 H701 H705 H711 H119 H123 H129 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 801 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1hy7 B 1.5 BS02 ZN B 2 H651 D653 H666 H679 H69 D71 H84 H97 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 802 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1hy7 B 1.5 BS03 CA B 1 D658 G659 G661 V663 D681 E684 D76 G77 G79 V81 D99 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 803 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1hy7 B 1.5 BS04 CA B 2 D607 D682 E684 D25 D100 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 804 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1hy7 B 1.5 BS05 CA B 3 D641 G673 N675 D677 D59 G91 N93 D95 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 11297453 805 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1hy7 B 1.5 BS06 MBS B 1 V663 L664 A665 H666 H701 E702 H711 L718 Y720 P721 L722 Y723 V81 L82 A83 H84 H119 E120 H129 L136 Y138 P139 L140 Y141 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 ic50=4090nM -logKd/Ki=5.39, IC50=4.09uM IC50=4090nM P08254 11297453 901 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRLSQDDINGIQSLYGPPPDSPET