1hv5 A 2.6 BS01 ZN A 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5501 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 A 2.6 BS02 ZN A 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5502 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 A 2.6 BS03 CA A 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5503 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 A 2.6 BS04 RXP A 1 L172 G179 I180 L181 A182 A184 Q215 H219 E220 F240 Y241 L72 G79 I80 L81 A82 A84 Q115 H119 E120 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.30, Ki=5nM Ki=5nM Q02853 11254383 6001 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 B 2.6 BS01 ZN B 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5504 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRP 1hv5 B 2.6 BS02 ZN B 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5505 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRP 1hv5 B 2.6 BS03 CA B 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5506 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRP 1hv5 B 2.6 BS04 RXP B 1 L172 G179 I180 L181 A182 A184 Q215 H219 E220 H223 F240 Y241 L72 G79 I80 L81 A82 A84 Q115 H119 E120 H123 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=5nM Q02853 11254383 6002 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRP 1hv5 C 2.6 BS01 ZN C 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5507 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 C 2.6 BS02 ZN C 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5508 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 C 2.6 BS03 CA C 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5509 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 C 2.6 BS04 RXP C 1 G179 I180 L181 A182 H183 A184 Q215 H219 E220 H223 H229 F240 Y241 G79 I80 L81 A82 H83 A84 Q115 H119 E120 H123 H129 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=5nM Q02853 11254383 6003 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 D 2.6 BS01 ZN D 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5510 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 D 2.6 BS02 ZN D 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5511 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 D 2.6 BS03 CA D 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5512 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 D 2.6 BS04 RXP D 1 G179 I180 L181 A182 A184 Q215 H219 E220 H229 L236 F240 Y241 G79 I80 L81 A82 A84 Q115 H119 E120 H129 L136 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=5nM Q02853 11254383 6004 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 E 2.6 BS01 ZN E 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5513 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQ 1hv5 E 2.6 BS02 ZN E 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5514 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQ 1hv5 E 2.6 BS03 CA E 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5515 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQ 1hv5 E 2.6 BS04 RXP E 1 I180 L181 A182 A184 Q215 H219 E220 H223 S238 F240 Y241 I80 L81 A82 A84 Q115 H119 E120 H123 S138 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=5nM Q02853 11254383 6005 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQ 1hv5 F 2.6 BS01 ZN F 1 H168 D170 H183 H196 H68 D70 H83 H96 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5516 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 F 2.6 BS02 ZN F 2 H219 H223 H229 H119 H123 H129 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5517 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 F 2.6 BS03 CA F 1 D175 G176 G178 I180 D198 E201 D75 G76 G78 I80 D98 E101 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Q02853 11254383 5518 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG 1hv5 F 2.6 BS04 RXP F 1 L172 G179 I180 L181 A182 A184 H219 E220 H229 F240 Y241 L72 G79 I80 L81 A82 A84 H119 E120 H129 F140 Y141 H219 E220 H223 H229 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=5nM Q02853 11254383 6006 MFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYG