1htb A 2.4 BS01 ZN A 1 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 375 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb A 2.4 BS02 ZN A 2 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 376 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb A 2.4 BS03 NAD A 1 C46 R47 T48 H51 C174 T178 G201 V203 D223 I224 K228 V268 I269 V292 G293 V294 L362 C46 R47 T48 H51 C174 T178 G201 V203 D223 I224 K228 V268 I269 V292 G293 V294 L362 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 377 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb A 2.4 BS04 PYZ A 1 T48 H67 F93 L116 C174 T48 H67 F93 L116 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 378 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb B 2.4 BS01 ZN B 1 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 375 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb B 2.4 BS02 ZN B 2 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 376 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb B 2.4 BS03 NAD B 1 C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318 C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 Kd=670uM P00325 8663387 377 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF 1htb B 2.4 BS04 PYZ B 1 T48 H67 F93 L116 C174 T48 H67 F93 L116 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 8663387 378 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSICTVLTF