1hqg A 2.0 BS01 MN A 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 500 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg A 2.0 BS02 MN A 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 501 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg A 2.0 BS03 ORN A 1 H126 N130 C141 D183 H121 N125 C136 D178 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 -logKd/Ki=3.00, Ki=1.0mM P07824 11258880 801 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg A 2.0 BS04 URE A 1 H101 C141 D232 E277 H96 C136 D227 E272 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 1901 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg B 2.0 BS01 MN B 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 502 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg B 2.0 BS02 MN B 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 503 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg B 2.0 BS03 ORN B 1 H126 N130 C141 D183 H121 N125 C136 D178 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 902 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg B 2.0 BS04 URE B 1 H101 C141 D232 E277 H96 C136 D227 E272 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 1902 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg C 2.0 BS01 MN C 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 504 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg C 2.0 BS02 MN C 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 505 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg C 2.0 BS03 ORN C 1 H126 N130 C141 D183 H121 N125 C136 D178 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 903 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqg C 2.0 BS04 URE C 1 H101 C141 D232 E277 H96 C136 D227 E272 H101 D124 H126 D128 C141 D232 D234 E277 H96 D119 H121 D123 C136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0004053,0005615,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 1903 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLCGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL