1h83 A 1.9 BS01 FAD A 1 V10 G11 G13 S15 E35 A36 G42 R43 G57 A58 N59 W60 V237 Y399 T402 F403 G429 E430 G438 Y439 V440 A443 V6 G7 G9 S11 E31 A32 G38 R39 G53 A54 N55 W56 V233 Y395 T398 F399 G425 E426 G434 Y435 V436 A439 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 O64411 11258887 579 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMC 1h83 A 1.9 BS02 DIA A 1 E62 E170 F171 F403 N437 G438 Y439 E58 E166 F167 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMC 1h83 B 1.9 BS01 FAD B 1 V10 G11 S15 E35 A36 G42 R43 G57 A58 N59 W60 V237 Y298 Y399 T402 F403 G429 E430 G438 Y439 V440 A443 V6 G7 S11 E31 A32 G38 R39 G53 A54 N55 W56 V233 Y294 Y395 T398 F399 G425 E426 G434 Y435 V436 A439 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 O64411 11258887 579 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH 1h83 B 1.9 BS02 DIA B 1 E62 F171 Y298 F403 N437 G438 Y439 E58 F167 Y294 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH 1h83 C 1.9 BS01 FAD C 1 V10 G11 G13 S15 E35 A36 G42 R43 G57 A58 N59 W60 V237 Y298 W393 Y399 T402 F403 G429 E430 G438 Y439 V440 A443 V6 G7 G9 S11 E31 A32 G38 R39 G53 A54 N55 W56 V233 Y294 W389 Y395 T398 F399 G425 E426 G434 Y435 V436 A439 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 O64411 11258887 579 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH 1h83 C 1.9 BS02 DIA C 1 E62 E170 F171 Y298 F403 N437 G438 Y439 E58 E166 F167 Y294 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH