1gcz A 1.9 BS01 YZ9 A 1 P1 K32 Y36 H62 S63 I64 V106 P1 K32 Y36 H62 S63 I64 V106 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM -logKd/Ki=5.13, Ki=7.4uM Ki=7400nM P14174 11170644 900 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFALEHH 1gcz A 1.9 BS02 YZ9 B 1 Y95 N97 Y95 N97 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM -logKd/Ki=5.13, Ki=7.4uM Ki=7400nM P14174 11170644 902 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFALEHH 1gcz B 1.9 BS01 YZ9 B 1 P1 M2 K32 H62 S63 I64 V106 F113 P1 M2 K32 H62 S63 I64 V106 F113 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM Ki=7400nM P14174 11170644 902 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA 1gcz B 1.9 BS02 YZ9 C 1 Y95 N97 Y95 N97 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM Ki=7400nM P14174 11170644 901 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA 1gcz C 1.9 BS01 YZ9 A 1 Y95 N97 Y95 N97 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM -logKd/Ki=5.13, Ki=7.4uM Ki=7400nM P14174 11170644 900 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFALEHH 1gcz C 1.9 BS02 YZ9 C 1 P1 M2 K32 H62 S63 I64 V106 F113 P1 M2 K32 H62 S63 I64 V106 F113 5.3.2.1,5.3.3.12 0001516,0001819,0001934,0002020,0002906,0004167,0005125,0005126,0005515,0005576,0005615,0005654,0005737,0005829,0005886,0006954,0007166,0008284,0009986,0010629,0010760,0016853,0019752,0030330,0030336,0030890,0031666,0031982,0032760,0033033,0034774,0042056,0042127,0042327,0042802,0043030,0043066,0043406,0043518,0045087,0048146,0050178,0050918,0051248,0061078,0061081,0070062,0070207,0070374,0090238,0090398,0141163,1902166,1904813,2000343,2000773 Ki=7.4uM -logKd/Ki=5.13, Ki=7.4uM Ki=7400nM P14174 11170644 901 PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFALEHH