1g3m A 1.7 BS01 A3P A 1 K47 G49 T50 T51 W52 R129 S137 Y192 F228 M255 R256 K257 G258 K45 G47 T48 T49 W50 R127 S135 Y190 F226 M253 R254 K255 G256 K47 H107 S137 K45 H105 S135 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 12782487 701 SELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRT 1g3m A 1.7 BS02 PCQ A 1 Y20 F23 P46 F80 K105 H107 F141 V145 A146 Y239 I246 Y18 F21 P44 F78 K103 H105 F139 V143 A144 Y237 I244 K47 H107 S137 K45 H105 S135 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 ic50~0.15nM P49888 12782487 712 SELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRT 1g3m B 1.7 BS01 A3P B 1 K47 G49 T50 T51 W52 R129 S137 Y192 F228 M255 R256 K257 G258 K45 G47 T48 T49 W50 R122 S130 Y185 F221 M248 R249 K250 G251 K47 H107 S137 K45 H100 S130 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 12782487 702 SELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRT 1g3m B 1.7 BS02 PCQ B 1 Y20 F80 K105 H107 F141 V145 A146 Y239 I246 Y18 F78 K98 H100 F134 V138 A139 Y232 I239 K47 H107 S137 K45 H100 S130 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 ic50~0.15nM -logKd/Ki=10.00, IC50=0.10nM P49888 12782487 711 SELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRT