1ew8 A 2.2 BS01 ZN A 1 D327 H331 H412 D327 H331 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 450 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 A 2.2 BS02 ZN A 2 D51 D369 H370 D51 D369 H370 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 451 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 A 2.2 BS03 PO4 A 1 D51 S102 R166 D327 H412 D51 S102 R166 D327 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 557 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 A 2.2 BS04 MG A 1 D51 T155 E322 D51 T155 E322 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 452 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 A 2.2 BS05 ZN A 3 D51 T155 E322 D51 T155 E322 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 453 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 A 2.2 BS06 PAE A 1 D51 D101 S102 R166 D327 H412 D51 D101 S102 R166 D327 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 Ki=5.5mM -logKd/Ki=2.26, Ki=5.5mM P00634 10850800 556 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS01 ZN B 1 D327 H331 H412 D327 H331 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 450 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS02 ZN B 2 D51 D369 H370 D51 D369 H370 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 451 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS03 PO4 B 1 D51 D101 S102 R166 D327 H412 D51 D101 S102 R166 D327 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 557 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS04 MG B 1 D51 T155 E322 D51 T155 E322 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 452 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS05 ZN B 3 D51 T155 E322 D51 T155 E322 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 P00634 10850800 453 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK 1ew8 B 2.2 BS06 PAE B 1 D101 S102 R166 H412 D101 S102 R166 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 D51 S102 D153 T155 R166 E322 D327 K328 H331 D369 H370 H412 3.1.3.1 0000287,0004035,0004721,0005515,0006470,0008270,0016787,0016791,0030288,0030613,0033748,0042597,0046872 Ki=5.5mM P00634 10850800 556 TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK