1ecq A 2.0 BS01 DXG A 1 N27 H32 T103 Y150 F152 K207 D235 N237 N289 H339 S340 N341 H368 R422 N25 H30 T101 Y148 F150 K205 D233 N235 N287 H337 S338 N339 H366 R420 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K203 K205 D233 N235 E258 N287 M288 D311 H337 N339 I363 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 Ki=1mM -logKd/Ki=3.00, Ki=1.0mM P0AES2 10769114 499 SQFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq A 2.0 BS02 MG A 1 D235 E260 N289 D233 E258 N287 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K203 K205 D233 N235 E258 N287 M288 D311 H337 N339 I363 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 P0AES2 10769114 498 SQFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq B 2.0 BS01 DXG B 1 N27 H32 T103 Y150 F152 K207 D235 N289 H339 S340 N341 H368 R422 N23 H28 T99 Y146 F148 K203 D231 N285 H335 S336 N337 H364 R418 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K201 K203 D231 N233 E256 N285 M286 D309 H335 N337 I361 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 Ki=1mM P0AES2 10769114 500 FTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq B 2.0 BS02 MG B 1 D235 E260 N289 D231 E256 N285 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K201 K203 D231 N233 E256 N285 M286 D309 H335 N337 I361 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 P0AES2 10769114 498 FTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq C 2.0 BS01 DXG C 1 N27 H32 T103 F152 K207 D235 N237 N289 H339 S340 N341 H368 R422 N24 H29 T100 F149 K204 D232 N234 N286 H336 S337 N338 H365 R419 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K202 K204 D232 N234 E257 N286 M287 D310 H336 N338 I362 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 Ki=1mM P0AES2 10769114 501 QFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq C 2.0 BS02 MG C 1 D235 E260 N289 D232 E257 N286 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K202 K204 D232 N234 E257 N286 M287 D310 H336 N338 I362 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 P0AES2 10769114 498 QFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq D 2.0 BS01 DXG D 1 N27 H32 T103 Y150 F152 K205 K207 D235 N289 H339 S340 N341 H368 R422 N23 H28 T99 Y146 F148 K201 K203 D231 N285 H335 S336 N337 H364 R418 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K201 K203 D231 N233 E256 N285 M286 D309 H335 N337 I361 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 Ki=1mM P0AES2 10769114 502 FTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR 1ecq D 2.0 BS02 MG D 1 D235 E260 N289 D231 E256 N285 K205 K207 D235 N237 E260 N289 M290 D313 H339 N341 I365 K201 K203 D231 N233 E256 N285 M286 D309 H335 N337 I361 4.2.1.40 0000287,0008872,0016829,0019394,0042838,0046872 P0AES2 10769114 498 FTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR