1dub A 2.5 BS01 CAA A 1 K56 A57 L58 A60 A96 A98 D99 I100 Y137 G140 G141 E144 P163 E164 L167 G172 K26 A27 L28 A30 A66 A68 D69 I70 Y107 G110 G111 E114 P133 E134 L137 G142 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A68 M73 S83 L87 G111 E114 P133 E134 T139 P141 G142 K227 F237 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM -logKd/Ki=5.80, Ki=1.6uM P14604 8895557 300 ANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub A 2.5 BS02 CAA C 1 F263 F279 F233 F249 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A68 M73 S83 L87 G111 E114 P133 E134 T139 P141 G142 K227 F237 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM -logKd/Ki=5.80, Ki=1.6uM P14604 8895557 300 ANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub B 2.5 BS01 CAA A 1 F279 K282 F248 K251 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM -logKd/Ki=5.80, Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub B 2.5 BS02 CAA B 1 K56 A57 L58 A60 A96 A98 D99 I100 M103 G140 G141 E144 P163 E164 L167 G172 K25 A26 L27 A29 A65 A67 D68 I69 M72 G109 G110 E113 P132 E133 L136 G141 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM -logKd/Ki=5.80, Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub C 2.5 BS01 CAA B 1 F263 F279 K282 F232 F248 K251 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub C 2.5 BS02 CAA C 1 A57 L58 A60 K92 A96 G97 A98 I100 Y137 G140 G141 E144 P163 E164 L167 G172 A26 L27 A29 K61 A65 G66 A67 I69 Y106 G109 G110 E113 P132 E133 L136 G141 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub D 2.5 BS01 CAA F 1 F263 F279 F233 F249 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A68 M73 S83 L87 G111 E114 P133 E134 T139 P141 G142 K227 F237 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 P14604 8895557 300 ANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub E 2.5 BS01 CAA E 1 K56 A57 L58 A60 K92 A96 A98 D99 I100 K101 G140 G141 E144 P163 E164 L167 G172 K26 A27 L28 A30 K62 A66 A68 D69 I70 K71 G110 G111 E114 P133 E134 L137 G142 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A68 M73 S83 L87 G111 E114 P133 E134 T139 P141 G142 K227 F237 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM P14604 8895557 300 ANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub F 2.5 BS01 CAA E 1 F263 F279 F232 F248 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH 1dub F 2.5 BS02 CAA F 1 K56 A57 L58 A60 K92 A96 A98 I100 M103 Y137 G140 G141 E144 P163 E164 L167 G172 K25 A26 L27 A29 K61 A65 A67 I69 M72 Y106 G109 G110 E113 P132 E133 L136 G141 A98 M103 S113 L117 G141 E144 P163 E164 T169 P171 G172 K257 F267 A67 M72 S82 L86 G110 E113 P132 E133 T138 P140 G141 K226 F236 4.2.1.17,5.3.3.8 0003824,0004165,0004300,0005739,0005759,0006631,0006635,0016829,0016836,0016853,0043956,0120092 Ki=1.6uM P14604 8895557 300 NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH