1dth A 2.0 BS01 ZN A 1 H142 H146 H152 H142 H146 H152 3.4.24.42 0004222,0006508,0008237 P15167 8610113 901 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth A 2.0 BS02 CA A 1 E9 D93 C197 N200 E9 D93 C197 N200 3.4.24.42 0004222,0006508,0008237 P15167 8610113 903 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth A 2.0 BS03 BAT A 1 L108 G109 L110 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 T171 Y176 L108 G109 L110 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 T171 Y176 3.4.24.42 0004222,0006508,0008237 ic50=6nM -logKd/Ki=8.22, IC50=6nM P15167 8610113 972 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth B 2.0 BS01 ZN B 1 H142 H146 H152 H142 H146 H152 3.4.24.42 0004222,0006508,0008237 P15167 8610113 902 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth B 2.0 BS02 CA B 1 E9 D93 C197 N200 E9 D93 C197 N200 3.4.24.42 0004222,0006508,0008237 P15167 8610113 904 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth B 2.0 BS03 BAT B 1 L108 G109 V138 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 Y176 L108 G109 V138 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 Y176 3.4.24.42 0004222,0006508,0008237 ic50=6nM P15167 8610113 973 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP