1d8f A 2.4 BS01 ZN A 1 H201 H205 H211 H119 H123 H129 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 301 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1d8f A 2.4 BS02 ZN A 2 H151 D153 H166 H179 H69 D71 H84 H97 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 302 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1d8f A 2.4 BS03 CA A 1 D158 G159 G161 V163 D181 E184 D76 G77 G79 V81 D99 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 303 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1d8f A 2.4 BS04 CA A 2 D107 D182 E184 D25 D100 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 304 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1d8f A 2.4 BS05 CA A 3 D141 G173 N175 D177 D59 G91 N93 D95 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 305 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1d8f B 2.4 BS01 ZN B 1 H701 H705 H711 H119 H123 H129 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 801 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d8f B 2.4 BS02 ZN B 2 H651 D653 H666 H679 H69 D71 H84 H97 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 802 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d8f B 2.4 BS03 CA B 1 D658 G659 G661 V663 D681 E684 D76 G77 G79 V81 D99 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 803 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d8f B 2.4 BS04 CA B 2 D607 D682 E684 D25 D100 E102 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 804 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d8f B 2.4 BS05 CA B 3 D641 G673 N675 D677 D59 G91 N93 D95 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 10669564 805 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1d8f B 2.4 BS06 SPI B 1 L664 A665 V698 H701 E702 H705 H711 P721 Y723 L82 A83 V116 H119 E120 H123 H129 P139 Y141 H701 E702 H705 H711 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 ic50=18nM -logKd/Ki=7.74, IC50=18nM IC50=18nM P08254 10669564 901 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET