1c3x A 2.4 BS01 PO4 A 1 G45 S46 R103 H105 N134 S223 G37 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 303 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x A 2.4 BS02 8IG A 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 -logKd/Ki=3.68, Ki=210uM P81989 10600382 306 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS01 PO4 B 1 G45 S46 R103 H105 N134 S223 G37 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 302 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS02 CA B 1 G126 E128 G110 E112 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 300 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS03 8IG B 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 -logKd/Ki=3.68, Ki=210uM P81989 10600382 305 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x C 2.4 BS01 PO4 C 1 S46 R103 N134 S223 S38 R87 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 301 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x C 2.4 BS02 8IG C 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 304 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR