1bzy A 2.0 BS01 IMU A 1 Y104 E133 D134 I135 D137 T138 G139 K140 T141 K165 F186 V187 L192 D193 Y101 E130 D131 I132 D134 T135 G136 K137 T138 K162 F183 V184 L189 D190 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Kd=4.6nM -logKd/Ki=8.34, Kd=4.6nM Ki=4.6nM P00492 10360366 300 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy A 2.0 BS02 POP A 1 K68 G69 K102 S103 Y104 D193 R199 K65 G66 K99 S100 Y101 D190 R196 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 10360366 400 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy B 2.0 BS01 IMU B 1 Y104 E133 D134 I135 D137 T138 G139 K140 T141 K165 F186 V187 L192 D193 Y101 E130 D131 I132 D134 T135 G136 K137 T138 K162 F183 V184 L189 D190 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Kd=4.6nM Ki=4.6nM P00492 10360366 300 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy B 2.0 BS02 POP B 1 K68 G69 K102 Y104 D193 R199 K65 G66 K99 Y101 D190 R196 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 10360366 400 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy C 2.0 BS01 IMU C 1 Y104 E133 D134 I135 D137 T138 G139 K140 T141 F186 V187 L192 D193 Y101 E130 D131 I132 D134 T135 G136 K137 T138 F183 V184 L189 D190 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Kd=4.6nM Ki=4.6nM P00492 10360366 300 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy C 2.0 BS02 POP C 1 K68 G69 L101 K102 Y104 D193 R199 K65 G66 L98 K99 Y101 D190 R196 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 10360366 400 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy D 2.0 BS01 IMU D 1 Y104 E133 D134 I135 D137 T138 G139 T141 K165 F186 V187 L192 D193 Y101 E130 D131 I132 D134 T135 G136 T138 K162 F183 V184 L189 D190 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Kd=4.6nM Ki=4.6nM P00492 10360366 300 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1bzy D 2.0 BS02 POP D 1 K68 G69 K102 Y104 R199 K65 G66 K99 Y101 R196 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 10360366 400 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA