1bug A 2.7 BS01 CU A 1 H88 H109 H118 H88 H109 H118 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 Q9ZP19 9846879 500 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL 1bug A 2.7 BS02 CU A 2 H240 H244 H274 H240 H244 H274 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 Q9ZP19 9846879 501 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL 1bug A 2.7 BS03 URS A 1 H88 H109 H240 H244 M258 N260 F261 H274 H88 H109 H240 H244 M258 N260 F261 H274 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 -logKd/Ki=4.37, IC50=43uM Q9ZP19 9846879 1002 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL 1bug B 2.7 BS01 CU B 1 H88 H109 H118 H88 H109 H118 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 Q9ZP19 9846879 500 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL 1bug B 2.7 BS02 CU B 2 H240 H244 H274 H240 H244 H274 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 Q9ZP19 9846879 501 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL 1bug B 2.7 BS03 URS B 1 H88 H109 H240 H244 M258 N260 F261 H274 H88 H109 H240 H244 M258 N260 F261 H274 H88 H109 H118 H240 H244 F261 H274 H88 H109 H118 H240 H244 F261 H274 1.10.3.1 0004097,0016491 Q9ZP19 9846879 1002 APIQAPEISKCVVPPADLPPGAVVDNCCPPVASNIVDYKLPAVTTMKVRPAAHTMDKDAIAKFAKAVELMKALPADDPRNFYQQALVHCAYCNGGYDQVNFPDQEIQVHNSWLFFPFHRWYLYFYERILGKLIGDPSFGLPFWNWDNPGGMVLPDFLNDSTSSLYDSNRNQSHLPPVVVDLGYNGADTDVTDQQRITDNLALMYKQMVTNAGTAELFLGKAYRAGDAPSPGAGSIETSPHIPIHRWVGDPRNTNNEDMGNFYSAGRDIAFYCHHSNVDRMWTIWQQLARDYTDSDWLNATFLFYDENGQAVKVRIGDSLDNQKMGYKYAKTPLPWL