1biw A 2.5 BS01 ZN A 1 H201 H205 H211 H119 H123 H129 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 301 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1biw A 2.5 BS02 ZN A 2 H151 D153 H166 H179 H69 D71 H84 H97 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 302 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1biw A 2.5 BS03 CA A 1 D158 G159 G161 V163 D181 E184 D76 G77 G79 V81 D99 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 303 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1biw A 2.5 BS04 CA A 2 D107 D182 E184 D25 D100 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 304 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1biw A 2.5 BS05 CA A 3 D141 G173 N175 D177 D59 G91 N93 D95 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 305 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPD 1biw B 2.5 BS01 ZN B 1 H201 H205 H211 H119 H123 H129 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 801 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1biw B 2.5 BS02 ZN B 2 H151 D153 H166 H179 H69 D71 H84 H97 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 802 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1biw B 2.5 BS03 CA B 1 D158 G159 G161 V163 D181 E184 D76 G77 G79 V81 D99 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 803 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1biw B 2.5 BS04 CA B 2 D107 D182 E184 D25 D100 E102 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 804 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1biw B 2.5 BS05 CA B 3 D141 G173 N175 D177 D59 G91 N93 D95 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 P08254 9873489 805 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 1biw B 2.5 BS06 S80 B 1 N162 V163 L164 V198 H201 E202 H205 H211 P221 L222 Y223 N80 V81 L82 V116 H119 E120 H123 H129 P139 L140 Y141 H201 E202 H205 H211 H119 E120 H123 H129 3.4.24.17 0004222,0006508,0008237,0008270,0031012 ic50=104nM -logKd/Ki=6.98, IC50=104nM IC50=104nM P08254 9873489 401 FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET