1alw A 2.03 BS01 CA A 1 A107 D110 E112 E117 A14 D17 E19 E24 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 1 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw A 2.03 BS02 CA A 2 D150 D152 T154 K156 E161 D57 D59 T61 K63 E68 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 2 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw A 2.03 BS03 CA A 3 D180 D182 S184 T186 E191 D87 D89 S91 T93 E98 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 3 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw A 2.03 BS04 CA A 4 D135 D223 D225 N226 D42 D130 D132 N133 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 4 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw A 2.03 BS05 ISA A 1 H129 Q173 H36 Q80 F162 G185 I187 F69 G92 I94 ? 0005509 Ki=0.3uM -logKd/Ki=6.52, Ki=0.3uM P04574 9228946 11 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw B 2.03 BS01 CA B 1 A107 D110 E112 E117 A14 D17 E19 E24 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 5 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw B 2.03 BS02 CA B 2 D150 D152 T154 K156 E161 D57 D59 T61 K63 E68 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 6 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw B 2.03 BS03 CA B 3 D180 D182 S184 T186 E191 D87 D89 S91 T93 E98 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 7 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw B 2.03 BS04 CA B 4 D135 D223 D225 N226 D42 D130 D132 N133 F162 G185 I187 F69 G92 I94 ? 0005509 P04574 9228946 8 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 1alw B 2.03 BS05 ISA B 1 V125 H129 Q173 F224 V32 H36 Q80 F131 F162 G185 I187 F69 G92 I94 ? 0005509 Ki=0.3uM P04574 9228946 12 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS