1ahx A 2.0 BS01 PLP A 1 G107 G108 S109 W140 N194 D222 A224 Y225 S255 S257 K258 R266 G102 G103 S104 W130 N183 D211 A213 Y214 S243 S245 K246 R254 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 P00509 7664122 410 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ahx A 2.0 BS02 HCI A 1 I17 L18 G38 W140 K258 R386 I13 L14 G34 W130 K246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=120uM -logKd/Ki=3.92, Kd=120uM P00509 7664122 411 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ahx B 2.0 BS01 PLP B 1 G108 S109 W140 N194 D222 A224 Y225 S255 S257 K258 R266 G103 S104 W130 N183 D211 A213 Y214 S243 S245 K246 R254 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 P00509 7664122 410 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL 1ahx B 2.0 BS02 HCI B 1 I17 L18 I37 G38 W140 K258 R386 I13 L14 I33 G34 W130 K246 R374 W140 D222 A224 K258 W130 D211 A213 K246 2.6.1.1 0003824,0004069,0004838,0005737,0005829,0006520,0008483,0009058,0009094,0030170,0033585,0042802,0042803 Kd=120uM -logKd/Ki=3.92, Kd=120uM P00509 7664122 411 MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVKKAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSSPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL