1a4q A 1.9 BS01 CA A 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 P27907 9526556 2 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL 1a4q A 1.9 BS02 DPC A 1 R115 E116 D148 W176 I220 R222 A244 E274 E275 R291 N293 R373 Y408 R40 E41 D73 W101 I145 R147 A169 E199 E200 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=3.6uM -logKd/Ki=5.44, IC50=3.6uM P27907 9526556 466 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL 1a4q B 1.9 BS01 CA B 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 P27907 9526556 2 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL 1a4q B 1.9 BS02 DPC B 1 R115 E116 D148 R149 I220 R222 A244 E274 E275 R291 N293 R373 Y408 R40 E41 D73 R74 I145 R147 A169 E199 E200 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=3.6uM P27907 9526556 466 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL