1a4m A 1.95 BS01 ZN A 1 H15 H17 H214 D295 H12 H14 H211 D292 H15 H17 H214 E217 H238 D295 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 P03958 9622483 400 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m A 1.95 BS02 PRH A 1 H17 D19 F61 L62 F65 M155 G184 H214 E217 D295 D296 H14 D16 F58 L59 F62 M152 G181 H211 E214 D292 D293 H15 H17 H214 E217 H238 D295 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 Ki~0.1pM -logKd/Ki=13.00, Ki~0.1pM P03958 9622483 354 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m B 1.95 BS01 ZN B 1 H515 H517 H714 D795 H12 H14 H211 D292 H515 H517 H714 E717 H738 D795 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 P03958 9622483 900 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m B 1.95 BS02 PRH B 1 H517 D519 F561 L562 F565 M655 G684 H714 E717 D795 D796 H14 D16 F58 L59 F62 M152 G181 H211 E214 D292 D293 H515 H517 H714 E717 H738 D795 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 Ki~0.1pM P03958 9622483 854 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m C 1.95 BS01 ZN C 1 H1015 H1017 H1214 D1295 H12 H14 H211 D292 H1015 H1017 H1214 E1217 H1238 D1295 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 P03958 9622483 1400 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m C 1.95 BS02 PRH C 1 H1017 D1019 F1061 F1065 M1155 G1184 H1214 E1217 D1295 D1296 H14 D16 F58 F62 M152 G181 H211 E214 D292 D293 H1015 H1017 H1214 E1217 H1238 D1295 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 Ki~0.1pM P03958 9622483 1354 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m D 1.95 BS01 ZN D 1 H1515 H1517 H1714 D1795 H12 H14 H211 D292 H1515 H1517 H1714 E1717 H1738 D1795 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 P03958 9622483 1900 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 1a4m D 1.95 BS02 PRH D 1 H1517 D1519 F1561 L1562 F1565 M1655 G1684 H1714 E1717 D1795 D1796 H14 D16 F58 L59 F62 M152 G181 H211 E214 D292 D293 H1515 H1517 H1714 E1717 H1738 D1795 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 Ki~0.1pM P03958 9622483 1854 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ