4u0x A 2.03 BS01 ZXM A 1 S64 Q120 Y150 G314 S315 T316 R340 S61 Q117 Y147 G311 S312 T313 R337 S64 K67 Y150 E272 K312 S315 S61 K64 Y147 E269 K309 S312 3.5.2.6 0008800,0016787,0017001,0030288,0046677 Q6DRA1 25380506 401 KDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIK 4u0x B 2.03 BS01 ZXM B 1 S64 Y150 G314 S315 T316 R340 S64 Y150 G314 S315 T316 R340 S64 K67 Y150 E272 K312 S315 S64 K67 Y150 E272 K312 S315 3.5.2.6 0008800,0016787,0017001,0030288,0046677 -logKd/Ki=6.23, Kd=590nM Q6DRA1 25380506 401 NTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIK 4u0x C 2.03 BS01 ZXM C 1 S64 Y150 G314 S315 T316 S317 R340 S62 Y148 G312 S313 T314 S315 R338 S64 K67 Y150 E272 K312 S315 S62 K65 Y148 E270 K310 S313 3.5.2.6 0008800,0016787,0017001,0030288,0046677 Q6DRA1 25380506 401 PKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIK 4u0x D 2.03 BS01 ZXM D 1 S64 Y150 G314 S315 T316 R340 N343 S62 Y148 G310 S311 T312 R336 N339 S64 K67 Y150 E272 K312 S315 S62 K65 Y148 E270 K308 S311 3.5.2.6 0008800,0016787,0017001,0030288,0046677 Q6DRA1 25380506 401 PKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAIEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNA 5ee8 A 1.54 BS01 ZXM A 1 M69 S70 S130 N132 E166 T167 N170 T235 A237 R243 M44 S45 S105 N107 E141 T142 N145 T210 A212 R218 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 -logKd/Ki=6.89, IC50=0.13uM P0AD64 26729491 301 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR 5eec A 1.87 BS01 ZXM A 1 C69 S70 W105 S130 N132 E166 N170 T235 T237 C238 G239 C44 S45 W80 S105 N107 E141 N145 T210 T212 C213 G214 S70 K73 S130 E166 K234 T237 S45 K48 S105 E141 K209 T212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 -logKd/Ki=7.10, IC50=0.08uM Q9F663 26729491 301 LTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLG 5eec B 1.87 BS01 ZXM B 1 S70 W105 S130 N132 E166 L167 N170 T235 G236 T237 C238 S45 W80 S105 N107 E141 L142 N145 T210 G211 T212 C213 S70 K73 S130 E166 K234 T237 S45 K48 S105 E141 K209 T212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Q9F663 26729491 301 LTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLG 5zyb A 2.13 BS01 ZXM A 1 S65 Q121 Y151 Y223 G314 S315 S59 Q115 Y145 Y217 G304 S305 S65 K68 Y151 E272 K312 S315 S59 K62 Y145 E266 K302 S305 3.5.2.6 0008800,0016787,0017001,0030288,0046677,0046872 Q51578 401 DPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG 8sdt A 1.38 BS01 ZXM A 1 S90 Y177 Y249 G344 S345 T346 N347 S62 Y149 Y221 G316 S317 T318 N319 3.5.2.6 0008800,0017001,0030288 P24735 37850746 402 APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLE 8sdv A 1.42 BS01 ZXM A 1 S64 Q120 Y151 G318 S319 T320 S62 Q118 Y149 G316 S317 T318 3.5.2.6 0008800,0017001,0030288 P24735 37850746 402 APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLE