1h2y A 1.78 BS01 ZPR A 1 M235 F473 F476 S554 N555 A594 W595 R643 V644 M235 F473 F476 S554 N555 A594 W595 R643 V644 F473 S554 D641 H680 F473 S554 D641 H680 3.4.21.26 0004252,0005737,0005829,0006508,0008236,0070012 IC50=0.33nM P23687 12202494 791 MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGFGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP 1qfs A 2.0 BS01 ZPR A 1 M235 Y473 F476 S554 N555 A594 W595 R643 V644 M235 Y473 F476 S554 N555 A594 W595 R643 V644 Y473 S554 D641 H680 Y473 S554 D641 H680 3.4.21.26 0004252,0005737,0005829,0006508,0008236,0070012 -logKd/Ki=9.48, IC50=0.33nM IC50=0.33nM P23687 9695945 791 MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP 3iuq A 2.1 BS01 ZPR A 1 F461 S538 W579 F447 S524 W565 Y458 S538 N622 Y444 S524 N608 3.4.21.26 0004252,0005829,0006508,0008236,0016787,0070012 Q9X6R4 20444688 700 LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIPYRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDDRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVALPGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPSTMVTTADHNDRVVPAHSFKFAATLQADNAGPHPQLIRIETTPVAKLIEQSADIYAFTLYEMGYRELPR 3ivm A 2.05 BS01 ZPR A 1 Y458 F461 S538 N539 W579 R624 Y452 F455 S532 N533 W573 R618 Y458 S538 D622 H657 Y452 S532 D616 H651 3.4.21.26 0004252,0005829,0006508,0008236,0016787,0070012 Q9X6R4 20444688 999 LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIPYRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDDRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVALPGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAGHGAGTPVAKLIEQSADIYAFTLYEMGYRELPR 3ivm A 2.05 BS02 ZPR A 2 Y456 R535 G537 V562 H657 S670 Y674 Y450 R529 G531 V556 H651 S664 Y668 Y458 S538 D622 H657 Y452 S532 D616 H651 3.4.21.26 0004252,0005829,0006508,0008236,0016787,0070012 Q9X6R4 20444688 1000 LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIPYRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDDRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVALPGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAGHGAGTPVAKLIEQSADIYAFTLYEMGYRELPR 3muo A 1.95 BS01 ZPR A 1 T253 Y458 F461 S538 N539 W579 R624 V625 T247 Y452 F455 S532 N533 W573 R618 V619 Y458 S538 D622 H657 Y452 S532 D616 H651 3.4.21.26 0004252,0005829,0006508,0008236,0016787,0070012 Q9X6R4 701 LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIPYRAAIKEKLAASWNYAKEGAPFWWGRYHYFFKNDGLQNQNVLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDQRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVALPGLGSVSGFNGYWWDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAGHGAGTPVAKLIEQSADIYAFTLYEMGYRELPRQP 3muo A 1.95 BS02 ZPR A 2 Y456 Y483 R535 G537 V562 H657 S670 Y674 Y450 Y477 R529 G531 V556 H651 S664 Y668 Y458 S538 D622 H657 Y452 S532 D616 H651 3.4.21.26 0004252,0005829,0006508,0008236,0016787,0070012 Q9X6R4 702 LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIPYRAAIKEKLAASWNYAKEGAPFWWGRYHYFFKNDGLQNQNVLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDQRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVALPGLGSVSGFNGYWWDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAGHGAGTPVAKLIEQSADIYAFTLYEMGYRELPRQP 5uw6 A 3.3 BS02 ZPR A 1 F178 H239 Y481 F484 S562 N563 L602 W603 F167 H215 Y451 F454 S532 N533 L572 W573 Y481 S562 D653 H695 Y451 S532 D623 H665 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 YPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPWI 5uw6 B 3.3 BS02 ZPR B 1 H239 C259 Y481 F484 S562 N563 W603 R655 V656 H227 C247 Y463 F466 S544 N545 W585 R637 V638 H695 H677 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 ATSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPAVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESSAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPWID 5uw6 C 3.3 BS02 ZPR C 1 H239 C259 Y481 F484 S562 N563 W603 R655 H223 C243 Y459 F462 S540 N541 W581 R633 Y481 S562 D653 H695 Y459 S540 D631 H673 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 GFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPWI 5uw6 D 3.3 BS02 ZPR D 1 F178 H239 Y481 F484 S562 W603 R655 F175 H222 Y455 F458 S536 W577 R629 H695 H669 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 SGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPWI 5uzw A 2.82 BS02 ZPR A 1 F178 H239 C259 Y481 F484 S562 N563 L602 W603 R655 F167 H215 C235 Y451 F454 S532 N533 L572 W573 R625 Y481 S562 D653 Y451 S532 D623 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 YPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRATMTQIAEVADRYGFMAKALEAPWI 5uzw B 2.82 BS02 ZPR B 1 F178 C259 Y481 F484 S562 N563 L599 L602 W603 R655 F178 C248 Y464 F467 S545 N546 L582 L585 W586 R638 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 MATSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPAVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESSAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRRATMTQIAEVADRYGFMAKALEAPWID 5uzw C 2.82 BS02 ZPR C 1 H239 Y481 F484 S562 N563 W603 H223 Y460 F463 S541 N542 W582 Y481 S562 D653 Y460 S541 D632 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 GFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLESFRAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRGRATMTQIAEVADRYGFMAKALEAPWI 5uzw D 2.82 BS02 ZPR D 1 H239 Y481 F484 S562 N563 L599 L602 W603 H218 Y447 F450 S528 N529 L565 L568 W569 3.4.21.-,3.4.21.26 0004252,0005829,0006508,0008236,0046872,0070012 R4P353 28584123 801 TSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLPNGLAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKGRATMTQIAEVADRYGFMAKALEAPWI 7vgc A 2.722 BS01 ZPR A 1 F198 F273 Y276 Y482 F485 S562 N563 N600 W604 Y608 R648 V649 F170 F245 Y248 Y454 F457 S534 N535 N572 W576 Y580 R620 V621 0004252,0006508,0008236 35647921 801 SHNYPDTATVDQQDDYFGTAVTDPYRWLEQQDSKLVKDWVTAQNDFSLPTLKALPHWQKINDRLTELWQYERYGVPYKKAGQVFYEYNDGSWDQSVFYRTADIHKDGHVILDPRALSKDGTIAAKRYTVSPNGRYLAYGTSDGGTDWTDYRVRDLKTRRMIPDHLTGIKFSDASWAKDESGFYYSRYPFKEDGSADDSKQVSVYFHKIGEPQSKDQLIYKITDHPTRNPGAQVSDDGKYLILGVFDGYDSNGIYYKDLQDGESRVVKLLDDWDALYTYLGNQGKTFYFETNVDATNGRIIAIDIDKPQKDHWKILVPEQKDALQSASLIGGRFVLHYLEDAKSKVVVTDLDGKQQYALKLPGMGTVEGFTGDPDDPETYYAFSNFLTPPSIYKLNVHSGNSEIVKSPKYPADFSDYVVSQEFFTSKDGTRVPLFLVHKKGLKKYGKNPTLLYGYGGFNAAQLPRFYTRFAGWLDMGGTFAMVNLRGGSEYGGAWHKAGTKLQKQNVFDDFIGAAEWLIEEKITSPEKLGIMGRSNGGLLVGATEVQRPELFAVALPIVGVLDMLRYHTASANARQWSSDYGLSENKAEFNALYAYSPVHNTKKGTCYPATLITTADRDDRVVPWHSYKFAASLQRDQGCDNPIYLAVETRAGHGAGKPVWMQVEDFTNQYAFLADQLGLQ 7zaz AAA 2.0 BS01 ZPR AAA 1 F204 Y499 F502 S580 N581 F617 W621 R667 F200 Y495 F498 S576 N577 F613 W617 R663 0004252,0006508,0008236 801 GWGPYPPVERDETSAITYSSKLHGSVTVRDPYSQLEVPFEDSEETKAFVHSQRKFARTYLDENPDREAWLETLKKSWNYRRFSALKPESDGHYYFEYNDGLQSQLSLYRVRMGEEDTVLTESGPGGELFFNPNLLSLDGNAALTGFVMSPCGNYWAYGVSEHGSDWMSIYVRKTSSPHLPSQERGKDPGRMNDKIRHVRFFIVSWTSDSKGFFYSRYPPEDDEGKGNAPAMNCMVYYHRIGEDQESDVLVHEDPEHPFWISSVQLTPSGRYILFAASRDASHTQLVKIADLHENDIGTNMKWKNLHDPWEARFTIVGDEGSKIYFMTNLKAKNYKVATFDANHPDEGLTTLIAEDPNAFLVSASIHAQDKLLLVYLRNASHEIHIRDLTTGKPLGRIFEDLLGQFMVSGRRQDNDIFVLFSSFLSPGTVYRYTFGEEKGYRSLFRAISIPGLNLDDFMTESVFYPSKDGTSVHMFITRPKDVLLDGTSPVLQYGYGGFSLAMLPTFSLSTLLFCKIYRAIYAIPNIRGGSEYGESWHREGMLDKKQNVFDDFNAATEWLIANKYASKDRIAIRGGSNGGVLTTACANQAPGLYRCVITIEGIIDMLRFPKFTFGASWRSEYGDPEDPEDFDFIFKYSPYHNIPPPGDTVMPAMLFFTAAYDDRVSPLHTFKHVAALQHNFPKGPNPCLMRIDLNSGHFAGKSTQEMLEETADEYSFIGKSMGLTMQT 7zaz BBB 2.0 BS04 ZPR BBB 1 F204 Y499 F502 S580 N581 I606 W621 F187 Y482 F485 S563 N564 I589 W604 0004252,0006508,0008236 807 GWGPYPPVERDETSAITYSSKLHGSVTVRDPYSQLEVPFEDSEETKAFVHSQRKFARTYLDENPDREAWLETLKKSWNYRRFSALKPESDGHYYFEYNDGLQSQLSLYRVRMGEEDTVLTESGPGGELFFNPNLLSLDGNAALTGFVMSPCGNYWAYGVSEHGSDWMSIYVRKTSSPMNDKIRHVRFFIVSWTSDSKGFFYSRYPPEDDEGKGNAPAMNCMVYYHRIGEDQESDVLVHEDPEHPFWISSVQLTPSGRYILFAASRDASHTQLVKIADLHENDIGTNMKWKNLHDPWEARFTIVGDEGSKIYFMTNLKAKNYKVATFDANHPDEGLTTLIAEDPNAFLVSASIHAQDKLLLVYLRNASHEIHIRDLTTGKPLGRIFEDLLGQFMVSGRRQDNDIFVLFSSFLSPGTVYRYTFGEEKGYRSLFRAISIPGLNLDDFMTESVFYPSKDGTSVHMFITRPKDVLLDGTSPVLQYGYGGFSLAMLPTFSLSTLLFCKIYRAIYAIPNIRGGSEYGESWHREGMLDKKQNVFDDFNAATEWLIANKYASKDRIAIRGGSNGGVLTTACANQAPGLYRCVITIEGIIDMLRFPKFTFGASWRSEYGDPEDPEDFDFIFKYSPYHNIPPPGDTVMPAMLFFTAAYDDRVSPLHTFKHVAALQHNFPKGPNPCLMRIDKSTQEMLEETADEYSFIGKSMGLTMQT 7zaz CCC 2.0 BS04 ZPR CCC 1 Y499 F502 S580 N581 I606 F617 W621 Y467 F470 S548 N549 I574 F585 W589 0004252,0006508,0008236 806 WGPYPPVERDETSAITYSSKLHGSVTVRDPYSQLEVPFEDSEETKAFVHSQRKFARTYLDENPDREAWLETLKKSWNYRRFSALKPESDGHYYFEYNDGLQSQLSLYRVRMGEEDTVLTESGPGGELFFNPNLLSLDGNAALTGFVMSPCGNYWAYGVSWMSIYVRKTSSPMNDKIRHVRFFIVSWTSDSKGFFYSRYPPPAMNCMVYYHRIGEDQESDVLVHEDPEHPFWISSVQLTPSGRYILFAASRDASHTQLVKIADLHENDIGTNMKWKNLHDPWEARFTIVGDEGSKIYFMTNLKAKNYKVATFDANHPDEGLTTLIAEDPNAFLVSASIHAQDKLLLVYLRNASHEIHIRDLTTGKPLGRIFEDLLGQFMVSGRRQDNDIFVLFSSFLSPGTVYRYTFGEEKGYRSLFRAISIPGLNLDDFMTESVFYPSKDGTSVHMFITRPKDVLLDGTSPVLQYGYGGFSLAMLPTFSLSTLLFCKIYRAIYAIPNIRGGSEYGESWHREGMLDKKQNVFDDFNAATEWLIANKYASKDRIAIRGGSNGGVLTTACANQAPGLYRCVITIEGIIDMLRFPKFTFGASWRSEYGDPEDPEDFDFIFKYSPYHNIPPPGDTVMPAMLFFTAAYDDRVSPLHTFKHVAALQHNFPKGPNPCLMRIDKSTQEMLEETADEYSFIGKSMGLTMQ 7zaz DDD 2.0 BS01 ZPR DDD 1 R203 F204 Y499 F502 S580 N581 F617 W621 R667 R198 F199 Y488 F491 S569 N570 F606 W610 R656 0004252,0006508,0008236 801 WGPYPPVERDETSAITYSSKLHGSVTVRDPYSQLEVPFEDSEETKAFVHSQRKFARTYLDENPDREAWLETLKKSWNYRRFSALKPESDGHYYFEYNDGLQSQLSLYRVRMGEEDTVLTESGPGGELFFNPNLLSLDGNAALTGFVMSPCGNYWAYGVSEHGSDWMSIYVRKTSSPHLPSQERGKDPGRMNDKIRHVRFFIVSWTSDSKGFFYSRYPPGNAPAMNCMVYYHRIGEDQESDVLVHEDPEHPFWISSVQLTPSGRYILFAASRDASHTQLVKIADLHENDIGTNMKWKNLHDPWEARFTIVGDEGSKIYFMTNLKAKNYKVATFDANHPDEGLTTLIAEDPNAFLVSASIHAQDKLLLVYLRNASHEIHIRDLTTGKPLGRIFEDLLGQFMVSGRRQDNDIFVLFSSFLSPGTVYRYTFGEEKGYRSLFRAISIPGLNLDDFMTESVFYPSKDGTSVHMFITRPKDVLLDGTSPVLQYGYGGFSLAMLPTFSLSTLLFCKIYRAIYAIPNIRGGSEYGESWHREGMLDKKQNVFDDFNAATEWLIANKYASKDRIAIRGGSNGGVLTTACANQAPGLYRCVITIEGIIDMLRFPKFTFGASWRSEYGDPEDPEDFDFIFKYSPYHNIPPPGDTVMPAMLFFTAAYDDRVSPLHTFKHVAALQHNFPKGPNPCLMRIDLNSGKSTQEMLEETADEYSFIGKSMGLTMQT