2x7o A 3.7 BS01 ZOP A 1 I211 G212 V219 K232 L260 L278 S280 H283 H285 G286 R294 L340 I41 G42 V49 K62 L90 L108 S110 H113 H115 G116 R124 L170 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 -logKd/Ki=7.47, IC50=34nM EC50=105nM, IC50=34nM P36897 20919678 600 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 2x7o B 3.7 BS01 ZOP B 1 I211 G212 V219 A230 K232 E245 L260 L278 S280 Y282 H283 G286 R294 L340 I41 G42 V49 A60 K62 E75 L90 L108 S110 Y112 H113 G116 R124 L170 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 EC50=105nM, IC50=34nM P36897 20919678 600 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 2x7o C 3.7 BS01 ZOP C 1 I211 G212 V219 K232 E245 L260 L278 S280 Y282 H283 E284 G286 D290 R294 L340 I41 G42 V49 K62 E75 L90 L108 S110 Y112 H113 E114 G116 D120 R124 L170 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 EC50=105nM, IC50=34nM P36897 20919678 600 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 2x7o D 3.7 BS01 ZOP D 1 I211 G212 V219 K232 E245 L260 L278 S280 Y282 H283 E284 H285 G286 R294 L340 I41 G42 V49 K62 E75 L90 L108 S110 Y112 H113 E114 H115 G116 R124 L170 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 EC50=105nM, IC50=34nM P36897 20919678 600 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 2x7o E 3.7 BS01 ZOP E 1 I211 G212 V219 A230 K232 L260 L278 S280 Y282 H283 E284 H285 G286 R294 L340 I41 G42 V49 A60 K62 L90 L108 S110 Y112 H113 E114 H115 G116 R124 L170 D333 K335 N338 D351 T375 D163 K165 N168 D181 T205 2.7.11.30 0004672,0004675,0005524,0006468,0007178,0016020 EC50=105nM, IC50=34nM P36897 20919678 600 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG