1zw5 A 2.3 BS04 ZOL A 1 D117 R126 K214 T215 D257 K271 D89 R98 K186 T187 D229 K243 K71 F112 D117 D121 R126 D188 K214 F253 D257 D258 K43 F84 D89 D93 R98 D160 K186 F225 D229 D230 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 16684881 901 EKQDFVQHFSQIVRVLTEDEHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 2e91 A 2.14 BS03 ZOL A 1 D80 R89 Q147 K174 D214 K238 D77 R86 Q144 K171 D207 K228 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 -logKd/Ki=6.59, Ki=0.26uM IC50=6.6e+2nM, Ki=260nM Q12051 17535895 901 NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDDYLNLKDFQMSGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKN 2e91 B 2.14 BS03 ZOL B 1 D80 R89 Q147 K174 D214 K238 D69 R78 Q136 K163 D199 K216 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005737,0005739,0008299,0015031,0016114,0016740,0033384,0033386,0045337,0046872 IC50=6.6e+2nM, Ki=260nM Q12051 17535895 902 KMEAKIDELINNDPVWSSQNESLISKPYNHILLLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDDYLNLKDFQAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK 2f8c F 2.2 BS04 ZOL F 1 D103 R112 K200 T201 D243 K257 D96 R105 K193 T194 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 16892359 9001 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 2f8z F 2.6 BS04 ZOL F 1 D103 R112 K200 T201 D243 K257 D96 R105 K193 T194 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 16892359 5001 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 2f9k F 2.06 BS04 ZOL F 1 D103 R112 Q171 K200 T201 D243 K257 D96 R105 Q164 K193 T194 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 -logKd/Ki=7.07, Ki=85.9nM IC50=100nM, Ki=85.9nM P14324 16892359 9001 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 2q58 A 2.37 BS03 ZOL A 1 D1115 R1124 Q1184 K1210 T1211 Q1251 N1254 D93 R102 Q162 K188 T189 Q229 N232 D1255 D233 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 IC50=30.1nM, Ki=0.050nM Q5CR09 19101474 1 YDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITN 2q58 B 2.37 BS03 ZOL B 1 D2115 R2124 K2210 T2211 Q2251 N2254 D83 R92 K178 T179 Q219 N222 K2072 L2110 D2115 D2119 R2124 D2187 K2210 Y2250 N2254 D2255 K42 L78 D83 D87 R92 D155 K178 Y218 N222 D223 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 IC50=30.1nM, Ki=0.050nM Q5CR09 19101474 2 YDYTDFINYYDKFKVIVYNVLKKLPVIEYYLNCIDYNVKKGKHIRGKILVLISSLAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITNSRSN 3ez3 A 2.304 BS01 ZOL A 1 D126 R135 K243 T244 D287 K301 D92 R101 K205 T206 D249 K263 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K48 A87 D92 D96 R101 D164 K205 F245 D249 D250 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 A5K4U6 397 LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSEIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ez3 B 2.304 BS01 ZOL B 1 D126 R135 K243 T244 D287 K301 D87 R96 K202 T203 D244 K258 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K46 A82 D87 D91 R96 D159 K202 F240 D244 D245 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 A5K4U6 397 FFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIANLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ez3 C 2.304 BS01 ZOL C 1 D126 R135 Q195 K243 T244 D287 K301 D91 R100 Q160 K204 T205 D248 K262 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K48 A86 D91 D95 R100 D163 K204 F244 D248 D249 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 A5K4U6 397 LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSEIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ez3 D 2.304 BS01 ZOL D 1 D126 R135 K243 T244 D287 K301 D86 R95 K201 T202 D243 K257 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K45 A81 D86 D90 R95 D158 K201 F239 D243 D244 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 A5K4U6 397 FRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHEGIEYVLKYLLEILFTGV 3iba A 2.4 BS03 ZOL A 1 D98 R107 Q167 K207 D250 K264 D98 R107 Q167 K207 D250 K264 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 19876942 901 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK 3ldw A 2.47 BS01 ZOL A 1 D126 R135 Q195 K243 T244 D287 K301 D92 R101 Q161 K205 T206 D249 K263 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K48 A87 D92 D96 R101 D164 K205 F245 D249 D250 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 Ki=10.7nM -logKd/Ki=7.97, Ki=10.7nM A5K4U6 21084289 397 LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSEIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ldw B 2.47 BS01 ZOL B 1 D126 R135 Q195 K243 T244 D287 K301 D87 R96 Q156 K202 T203 D244 K258 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K46 A82 D87 D91 R96 D159 K202 F240 D244 D245 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 Ki=10.7nM A5K4U6 21084289 397 FFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIANLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ldw C 2.47 BS01 ZOL C 1 D126 R135 Q195 K243 T244 D287 K301 D91 R100 Q160 K204 T205 D248 K262 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K48 A86 D91 D95 R100 D163 K204 F244 D248 D249 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 Ki=10.7nM A5K4U6 21084289 397 LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSEIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3ldw D 2.47 BS01 ZOL D 1 D126 R135 Q195 K243 T244 D287 K301 D86 R95 Q155 K201 T202 D243 K257 K81 A121 D126 D130 R135 D198 K243 F283 D287 D288 K45 A81 D86 D90 R95 D158 K201 F239 D243 D244 ? 0004161,0004337,0004659,0005737,0008299,0016020,0016740,0016765,0045337,0046872 Ki=10.7nM A5K4U6 21084289 397 FRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV 3n45 F 1.88 BS02 ZOL F 1 D103 R112 K200 T201 D243 K257 D96 R105 K193 T194 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 20711197 354 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 3n46 F 2.35 BS02 ZOL F 1 D103 R112 Q171 K200 T201 Q240 D243 K257 D96 R105 Q164 K193 T194 Q233 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 20711197 354 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4kfa A 1.98 BS03 ZOL A 1 D103 R112 Q171 K200 D243 K257 D91 R100 Q159 K188 D231 K245 K57 F98 D103 D107 R112 D174 K200 F239 D243 D244 K45 F86 D91 D95 R100 D162 K188 F227 D231 D232 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 404 VYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKAAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4kq5 A 2.4 BS03 ZOL A 1 D103 R112 Q171 K200 T201 D243 K257 D95 R104 Q163 K192 T193 D235 K249 K57 F98 D103 D107 R112 D174 K200 F239 D243 D244 K49 F90 D95 D99 R104 D166 K192 F231 D235 D236 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 404 VYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFASFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4p0v A 2.4 BS01 ZOL A 1 D103 R112 K200 T201 D243 K257 D96 R105 K193 T194 D236 K250 K57 F98 D103 D107 R112 D174 K200 F239 D243 D244 K50 F91 D96 D100 R105 D167 K193 F232 D236 D237 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 24927548 401 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 4p0w A 2.406 BS02 ZOL A 1 D103 R112 K200 T201 D243 K257 D96 R105 K193 T194 D236 K250 K57 F98 D103 D107 R112 D174 K200 F239 D243 D244 K50 F91 D96 D100 R105 D167 K193 F232 D236 D237 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=100nM, Ki=85.9nM P14324 24927548 501 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 6g31 A 3.0 BS01 ZOL A 1 D64 R73 D60 R69 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 QETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 B 3.0 BS01 ZOL B 1 D64 D68 R73 D59 D63 R68 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 C 3.0 BS01 ZOL C 1 D64 D68 R73 Q126 K151 D61 D65 R70 Q123 K148 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 TQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSNKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 D 3.0 BS01 ZOL D 1 D64 D68 R73 D55 D59 R64 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPGTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 6g31 E 3.0 BS01 ZOL E 1 D64 D68 R73 D49 D53 R58 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 QETVQRILLEPYKYLLQLAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKNTLGLFFQIRYDYANLHSFCEDLTEGKFSFPTIHAIWSRPTQVQNILRQRTENIDIKKYCVHYGSFEYTRNTLKELEAKPELVALVKHLSKMFK 6g31 F 3.0 BS01 ZOL F 1 D64 D68 R73 Q126 D59 D63 R68 Q121 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 G 3.0 BS01 ZOL G 1 D64 Q126 K151 D62 Q124 K149 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 KTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKPLLNTLGLFFQIRYDYANLHSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 6g31 H 3.0 BS01 ZOL H 1 D64 D68 K212 D57 D61 K197 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 I 3.0 BS01 ZOL I 1 D64 K151 D60 K147 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 QETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLKSFCEDLTEGKFSFPTIHAIWSRPEVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDGNPELVALVKHLSKM 6g31 J 3.0 BS01 ZOL J 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 6g31 K 3.0 BS01 ZOL K 1 D64 D68 Q126 D60 D64 Q122 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 QETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKKPLLNTLGLFFQIRYDYANLHSSFCEDLTEGKFSFPTIHAIWSRPEQVQNILRQRTENIDIKKYCVHYLEDVGYTRNTLKELEAKAYKQPELVALVKHLSKMF 6g31 L 3.0 BS01 ZOL L 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 IC50=100000nM, Ki=2700nM O95749 30275041 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRYDYANLHSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 8a7c A 1.2 BS04 ZOL A 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 507 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7c B 1.2 BS04 ZOL B 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 505 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7j A 1.2 BS04 ZOL A 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 506 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7j B 1.2 BS04 ZOL B 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 506 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7k A 1.3 BS06 ZOL A 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 510 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7k B 1.3 BS06 ZOL B 1 D179 R188 Q247 K276 T277 D319 K333 D95 R104 Q163 K192 T193 D235 K249 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 509 SFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA 8a7l A 1.85 BS03 ZOL A 1 D179 R188 Q247 K276 T277 D319 K333 D96 R105 Q164 K193 T194 D236 K250 2.5.1.1 0004659,0008299,0016765 M1JS91 37308711 505 GSFSKEESREFMAIFPDIVRDLTDAGRHTDIPEVTKRFAKVLQYNVPTGKKTRGLSTVIAYKMLEKPENLTPENVRLAGILGWCVELLQASLLIMDDLMDRSETRRGQPCWYRQENVGFLAINDCLHVESSLYSVLRKYFSHLPCYVPIIELFHDVNFKTNMGQSLDALCMKDGRPILSQFTMKRYSSIVKYKTSYYTFQLPVSLGMYLADMYDPEQHRQAKTILMEIGEFFQIQDDFLDAFGDSQVTGKVGTDIKEGKCSWLAVVALQRSNPAQRQIMEEHYGRPEPESTQIIKNLYIELGLPATFAVYEEESFNIIRTHIHQISKGLPHDLFFKIMKKIYKRDA