3qnq A 3.295 BS01 ZDM A 1 P178 R182 A186 P176 R180 A184 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 443 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq A 3.295 BS02 ZDM A 2 D27 P34 R91 D25 P32 R89 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 600 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq B 3.295 BS01 ZDM A 1 P34 R91 P32 R89 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 443 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq B 3.295 BS02 ZDM A 2 P178 R182 A186 P176 R180 A184 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 600 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq C 3.295 BS01 ZDM C 1 P178 R182 P176 R180 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 443 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq C 3.295 BS02 ZDM C 2 D27 R91 D25 R89 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 600 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEA 3qnq D 3.295 BS01 ZDM C 1 D27 P34 R91 D25 P32 R89 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 443 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEAAAEN 3qnq D 3.295 BS02 ZDM C 2 P178 R182 P176 R180 2.7.1.69 0005886,0008982,0009401,0016020,0016740,0042802,1901264 Q72XQ0 21471968 600 RFLEKYVMPVAGKVAEQRHLLAIRDGLVLTMPFLIIGSIFLIISTLPIPGYSEFMASLFGKNWNVALGYPVSATFNIMALIAVFGIAYRLGEYYKVDALASGALSLVTFLLATPFQVAYIMPGTKESILVDGVIPAALMGSQGLFVAMIIAIISTEIYRFLVQKKMIIKMPETVPPAVTRSFAALIPGFIVVTVVWIIRLIFEHTTFGSIHNVVGKLLQEPLSILGASLWGAVIAVILVHVLWACGIHGATIVGGVMSPIWLSLMDQNRIAFQAGQDVPNTITAQFFDLWIYMGGSGATLALVVGMLLFARSQQLKSLGRLSIAPGIFNINEMVTFGMPIVMNPLLLIPFIVVPVVLTIVSYFAMEWGLVARPSGAAVTWTTPILFSGYLGSGGKISGVILQLVNFALAFVIYLPFLKIWDKQKIAEEKGEAAAEN 6eu6 A 1.98 BS01 ZDM A 1 P187 L314 K315 P187 L314 K315 2.7.13.3 0005886,0008519,0016020,0072488 -logKd/Ki=4.39, Kd=41uM Q1Q357 29323112 503 MENIQININHLWVIMAACMVFLMQLGFTSYETGFSQSKNAISIALRNLVDTLISSLVFFSVGFGFMFGKSYMGLIGIDLFFANDLALHPNTLSYSFFFFQMVFASTAATILTGAIAERSGFIPNIAGTAFIVAIIYPIFGHWAWGNLFSPDQTGWLKELGFIDFAGATVVHSIGGWFAMAAAIMVGPRIDKYNPDGSSNRIGLHNVPLATLGTFFLWFGWFGFNGGSLLRVSVNIGLVILNTNMAAASAGVSALIFIYATRKRIEAGSLFTAILAGLVAITASSNMVTPVSAVAIGLITGILAIIAEGFIEKTLKIDDPVSAIAVHGVGGVIGTLCVAIFAQKSYLLAENGSRMHQLGIQALGVIVAFSWSFGLGMLFFLCLKKVKRLRVTPEEEKRGLNVAEAA