6n95 A 1.798 BS01 YXS A 1 K24 L25 K60 A64 H66 D67 I68 H69 W108 G109 G110 T132 P133 L136 V138 Y140 F250 K253 K23 L24 K59 A63 H65 D66 I67 H68 W107 G108 G109 T131 P132 L135 V137 Y139 F249 K252 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM -logKd/Ki=5.12, Ki=7.5uM P52045 30869886 301 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6n95 B 1.798 BS01 YXS B 1 K60 A64 H66 D67 I68 W108 G109 G110 T132 P133 V138 Y140 K253 K59 A63 H65 D66 I67 W107 G108 G109 T131 P132 V137 Y139 K252 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM P52045 30869886 301 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6n95 C 1.798 BS01 YXS C 1 L25 A64 H66 D67 I68 W108 G109 G110 T132 P133 Y140 F250 L24 A63 H65 D66 I67 W107 G108 G109 T131 P132 Y139 F249 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM -logKd/Ki=5.12, Ki=7.5uM P52045 30869886 301 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6n95 D 1.798 BS01 YXS D 1 K60 A64 H66 D67 I68 W108 G109 G110 T132 P133 L136 Y140 F250 K253 K59 A63 H65 D66 I67 W107 G108 G109 T131 P132 L135 Y139 F249 K252 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM P52045 30869886 302 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6n95 E 1.798 BS01 YXS E 1 K24 L25 A64 H66 D67 I68 W108 G109 G110 T132 P133 Y140 K23 L24 A63 H65 D66 I67 W107 G108 G109 T131 P132 Y139 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM P52045 30869886 301 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6n95 F 1.798 BS01 YXS F 1 K24 L25 A64 H66 D67 I68 W108 G109 G110 T132 P133 Y140 K23 L24 A63 H65 D66 I67 W107 G108 G109 T131 P132 Y139 H66 L71 G110 E113 P133 V138 Y140 E228 Y238 H65 L70 G109 E112 P132 V137 Y139 E227 Y237 4.1.1.- 0003824,0004492,0005829,0006635,0016829,0016831 Ki=7.5uM P52045 30869886 301 AYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH 6x7o A 1.55 BS01 YXS A 1 A64 F65 K155 N216 L221 Y222 F223 Y260 L261 G262 N263 A55 F56 K146 N207 L212 Y213 F214 Y251 L252 G253 N254 ? 0016417 Q8GGP1 33482062 400 RPEIKQAVTVRPGMCGPGSLFVGQLGDWTWETVSAQCDTDVFAARDASGNPTYLAFYYFRVRGGRELHPGSLTFGDRLTVTSGCYDQGTESVLTLHRIDRAGSDDAQRPLDLHEFYERPRDGSLYVENFNRWVTRSAPGSNEDLVKSSPPGFRNDGLPQLPAAYSPRAVYREARTAHTFRALDEPGFRLLPDTVEVEHPVDIVRDVNGVGLLYFASYFSMVDKAALALWRRLGRSDRAFLRRVVVDQQMCYLGNADLDSVLTLGARVRVSTETPGEELVDVVISDRDSGRVIAVSTLHTQH