4ll0 A 4.0 BS01 YUN A 1 L718 V726 A743 M790 Q791 L792 M793 C797 D800 L844 L22 V30 A47 M94 Q95 L96 M97 C101 D104 L148 D837 A839 R841 N842 D855 D141 A143 R145 N146 D159 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24019492 1101 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMEEDMDVVDADEYL 4ll0 B 4.0 BS01 YUN B 1 L718 V726 A743 M790 Q791 L792 M793 C797 D800 L844 L21 V29 A46 M93 Q94 L95 M96 C100 D103 L147 D837 A839 R841 N842 D855 D140 A142 R144 N145 D158 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24019492 1101 APNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDEVDADEYL 4lrm A 3.526 BS01 YUN A 1 L718 A743 K745 L791 T793 L795 M796 C800 L847 T857 L23 A48 K50 L96 T98 L100 M101 C105 L152 T162 D840 A842 R844 N845 D858 G877 D145 A147 R149 N150 D163 G182 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24353160 1101 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR 4lrm B 3.526 BS01 YUN B 1 A743 K745 L791 T793 L795 M796 G799 C800 L847 T857 A49 K51 L97 T99 L101 M102 G105 C106 L153 T163 D840 A842 R844 N845 D858 G877 D146 A148 R150 N151 D164 G183 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24353160 1101 SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD 4lrm C 3.526 BS01 YUN C 1 A743 I744 K745 L791 I792 T793 L795 M796 C800 L847 A50 I51 K52 L98 I99 T100 L102 M103 C107 L154 D840 A842 R844 N845 D858 G877 D147 A149 R151 N152 D165 G184 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24353160 1101 PSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 4lrm D 3.526 BS01 YUN D 1 A743 I744 K745 L791 I792 T793 L795 M796 C800 L847 A48 I49 K50 L96 I97 T98 L100 M101 C105 L152 D840 A842 R844 N845 D858 G877 D145 A147 R149 N150 D163 G182 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24353160 1101 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVI 4lrm E 3.526 BS01 YUN E 1 L718 A743 K745 L791 T793 L795 M796 C800 L847 L22 A47 K49 L95 T97 L99 M100 C104 L151 D840 A842 R844 N845 D858 G877 D144 A146 R148 N149 D162 G181 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.62nM P00533 24353160 1101 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG